Cell death resistance is a key feature of tumor cells. One of the main anticancer therapies is
increasing the susceptibility of cells to death. Cancer cells have developed a capability of …

Oxygen free radical and lipid peroxides (oxidative stress) are highly reactive and represent
very damaging compounds. Oxidative stress could be a major contributing factor to the …

In obesity, accumulation of lipid in nonadipose tissues, or lipotoxicity, is associated with
endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and ultimately apoptosis. We …

Mitochondrial compromise is a fundamental contributor to pancreatic β-cell failure in
diabetes. Previous studies have demonstrated a broader role for tumor suppressor p53 that …

Human exposure to capsaicin, the most abundant pungent chili pepper component, is
ubiquitous. Evaluation of capsaicin's carcinogenic potential has produced variable results in …

Kaempferol is a natural flavonoid. Previous studies have reported that kaempferol has anti‐
proliferation activities and induces apoptosis in many cancer cell lines. However, there are …

Capsaicin is the pungent ingredient of chili peppers and is approved as a topical treatment
of neuropathic pain. The analgesia lasts for several months after a single treatment …

Capsaicin, the pungent ingredient of chili peppers, displays potent anti-neoplastic activity in
a wide array of human cancer cells. The present manuscript examines the signaling …

Capsaicin, one of the major pungent ingredients found in red peppers, has been recently
demonstrated to induce apoptosis in many types of malignant cell lines including colon …

The controlled intracellular release of nitrite is still an unmet challenge due to the lack of bio‐
friendly donors, and the antitumor effect of nitrite is limited by its physiologically inert activity …