Neuroblastoma, an embryonal cancer of the autonomic nervous system, is the most common
cancer diagnosed during the first year of life. Although neuroblastoma accounts for …

One crucial barrier to progress in the treatment of cancer has been the inability to control the
balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past …

Biologically active sphingolipids have key roles in the regulation of several fundamental
biological processes that are integral to cancer pathogenesis. Recent significant progress in …

For a long time necrosis was considered as an alternative to programmed cell death,
apoptosis. Indeed, necrosis has distinct morphological features and it is accompanied by …

Cancer chemopreventive agents are typically natural products or their synthetic analogs that
inhibit the transformation of normal cells to premalignant cells or the progression of …

Sphingolipids have emerged as bioeffector molecules, controlling various aspects of cell
growth and proliferation in cancer, which is becoming the deadliest disease in the world …

Tamoxifen (TAM) has been used in the treatment of breast cancer for over a decade. The
observed clinical efficacy of TAM has been attributed to both growth arrest and induction of …

Previous work has demonstrated that a subset of macrophages expresses a folate receptor
(FR) that can mediate internalization of folate-linked molecules, including imaging and …

Inherent or acquired drug resistance, which frequently characterizes cancer cells, is caused
by multiple mechanisms, including dysfunctional metabolism of the lipid second messenger …

In this chapter, roles of bioactive sphingolipids in the regulation of cancer pathogenesis and
therapy will be reviewed. Sphingolipids have emerged as bioeffector molecules, which …