Role of Notch signaling in regulating innate immunity and inflammation in health and disease
The Notch signaling pathway is conserved from Drosophila to mammals and is critically
involved in developmental processes. In the immune system, it has been established that …
involved in developmental processes. In the immune system, it has been established that …
The IL-20 cytokine family in rheumatoid arthritis and spondyloarthritis
TW Kragstrup, T Andersen, LD Heftdal, M Hvid… - Frontiers in …, 2018 - frontiersin.org
This review describes the IL-20 family of cytokines in rheumatoid arthritis (RA) and
spondyloartrhitits (SpA) including psoriatic arthritis. The IL-20 receptor (R) cytokines IL-19, IL …
spondyloartrhitits (SpA) including psoriatic arthritis. The IL-20 receptor (R) cytokines IL-19, IL …
Perspective: ambient air pollution: inflammatory response and effects on the lung's vasculature
G Grunig, LM Marsh, N Esmaeil… - Pulmonary …, 2014 - journals.sagepub.com
Particulates from air pollution are implicated in causing or exacerbating respiratory and
systemic cardiovascular diseases and are thought to be among the leading causes of …
systemic cardiovascular diseases and are thought to be among the leading causes of …
[HTML][HTML] Breast tumor and stromal cell responses to TGF-β and hypoxia in matrix deposition
CS Curran, PJ Keely - Matrix Biology, 2013 - Elsevier
The components that comprise the extracellular matrix (ECM) are integral to normal tissue
homeostasis as well as the development and progression of breast tumors. The secretion …
homeostasis as well as the development and progression of breast tumors. The secretion …
Discovery of Notch pathway-related genes for predicting prognosis and tumor microenvironment status in bladder cancer
X Sun, S Xin, W Li, Y Zhang, L Ye - Frontiers in Genetics, 2022 - frontiersin.org
Background: Notch signaling is a key regulator of immune cell differentiation and linked to
autoimmune diseases, tumorigenesis and tumor-induced immunomodulation. An …
autoimmune diseases, tumorigenesis and tumor-induced immunomodulation. An …
Interleukin (IL)-19 promoted skin wound healing by increasing fibroblast keratinocyte growth factor expression
DP Sun, CH Yeh, E So, LY Wang, TS Wei, MS Chang… - Cytokine, 2013 - Elsevier
BACKGROUND: Interleukin (IL)-19, a member of the IL-10 cytokine family, is involved in
keratinocyte proliferation in psoriasis. OBJECTIVES: We investigated the role of IL-19 in the …
keratinocyte proliferation in psoriasis. OBJECTIVES: We investigated the role of IL-19 in the …
Resistin-like Molecule α and Pulmonary Vascular Remodeling: A Multi-Strain Murine Model of Antigen and Urban Ambient Particulate Matter Co-Exposure
N Durmus, WC Chen, SH Park, LM Marsh… - International Journal of …, 2023 - mdpi.com
Pulmonary hypertension (PH) has a high mortality and few treatment options. Adaptive
immune mediators of PH in mice challenged with antigen/particulate matter (antigen/PM) …
immune mediators of PH in mice challenged with antigen/particulate matter (antigen/PM) …
Interleukin-19 Gene-Deficient Mice Promote Liver Fibrosis via Enhanced TGF-β Signaling, and the Interleukin-19-CCL2 Axis Is Important in the Direction of Liver …
N Ono, T Fujita, M Miki, K Nishiyama, T Izawa… - Biomedicines, 2023 - mdpi.com
IL-19 is a cytokine discovered by homologous searching with IL-10 and is produced by non-
immune cells, such as keratinocytes, in addition to immune cells, such as macrophages …
immune cells, such as keratinocytes, in addition to immune cells, such as macrophages …
The effects of antigen-specific IgG1 antibody for the pulmonary-hypertension-phenotype and B cells for inflammation in mice exposed to antigen and fine particles from …
SH Park, WC Chen, N Durmus, B Bleck, J Reibman… - PLoS …, 2015 - journals.plos.org
Air pollution is known to exacerbate chronic inflammatory conditions of the lungs including
pulmonary hypertension, cardiovascular diseases and autoimmune diseases. Directly …
pulmonary hypertension, cardiovascular diseases and autoimmune diseases. Directly …
Interleukin 13–and interleukin 17A–induced pulmonary hypertension phenotype due to inhalation of antigen and fine particles from air pollution
SH Park, WC Chen, N Esmaeil, B Lucas… - Pulmonary …, 2014 - journals.sagepub.com
Pulmonary hypertension has a marked detrimental effect on quality of life and life
expectancy. In a mouse model of antigen-induced pulmonary arterial remodeling, we have …
expectancy. In a mouse model of antigen-induced pulmonary arterial remodeling, we have …