The development of multicellular animals is initially controlled by maternal gene products
deposited in the oocyte. During the maternal-to-zygotic transition, transcription of zygotic …

Oct4, a class V POU-domain protein that is encoded by the Pou5f1 gene, is thought to be a
key transcription factor in the early development of mammals. This transcription factor plays …

Enhancers are developmentally controlled transcriptional regulatory regions whose
activities are modulated through histone modifications or histone variant deposition. In this …

Gastrulation in vertebrates is a conserved process, which involves transition from cellular
pluripotency to early precursors of ectoderm, mesoderm, and endoderm. Pluripotency …

Pluripotency is a developmental ground state that can be recreated by direct
reprogramming. Establishment of pluripotency is crucially dependent on the homeodomain …

The POU genes represent a diverse class of animal-specific transcription factors that play
important roles in neurogenesis, pluripotency, and cell-type specification. Although previous …

Avian species are important model animals for developmental biology and disease
research. However, unlike in mice, where clonal lines of pluripotent stem cells have enabled …

In contrast to transcriptional regulation, the function of alternative splicing (AS) in stem cells
is poorly understood. In mammals, MBNL proteins negatively regulate an exon program …

MYC plays various roles in pluripotent stem cells, including the promotion of somatic cell
reprogramming to pluripotency, the regulation of cell competition and the control of …

The neural crest is a vertebrate-specific stem cell population that helped drive the origin and
evolution of vertebrates. A distinguishing feature of these cells is their multi-germ layer …