Therapeutic properties of mesenchymal stromal/stem cells: the need of cell priming for cell-free therapies in regenerative medicine

V Miceli, M Bulati, G Iannolo, G Zito, A Gallo… - International Journal of …, 2021 - mdpi.com
Mesenchymal stromal/stem cells (MSCs) are multipotent adult stem cells that support
homeostasis during tissue regeneration. In the last decade, cell therapies based on the use …

Modulators of the balance between M1 and M2 macrophages during pregnancy

YH Zhang, M He, Y Wang, AH Liao - Frontiers in immunology, 2017 - frontiersin.org
Macrophages are a subset of mononuclear phagocytes of the innate immune system with
high plasticity and heterogeneity. At the maternal–fetal interface, macrophages are present …

MSC-derived extracellular vesicles attenuate immune responses in two autoimmune murine models: type 1 diabetes and uveoretinitis

T Shigemoto-Kuroda, JY Oh, D Kim, HJ Jeong, SY Park… - Stem cell reports, 2017 - cell.com
Accumulating evidence shows that extracellular vesicles (EVs) produced by mesenchymal
stem/stromal cells (MSCs) exert their therapeutic effects in several disease models. We …

[HTML][HTML] Enzymatic and non-enzymatic isolation systems for adipose tissue-derived cells: current state of the art

E Oberbauer, C Steffenhagen, C Wurzer, C Gabriel… - Cell Regeneration, 2015 - Elsevier
In the past decade, adipose tissue became a highly interesting source of adult stem cells for
plastic surgery and regenerative medicine. The isolated stromal vascular fraction (SVF) is a …

The long path of human placenta, and its derivatives, in regenerative medicine

AR Silini, A Cargnoni, M Magatti, S Pianta… - … in bioengineering and …, 2015 - frontiersin.org
In the 1800s, a baby born with a caul, a remnant of the amniotic sack or fetal membranes,
was thought to be lucky, special, or protected. Over time, fetal membranes lost their …

Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells

PM Chen, ML Yen, KJ Liu, HK Sytwu… - Journal of Biomedical …, 2011 - Springer
In recent years, a large number of studies have contributed to our understanding of the
immunomodulatory mechanisms used by multipotent mesenchymal stem cells (MSCs) …

Amniotic membrane mesenchymal cells-derived factors skew T cell polarization toward Treg and downregulate Th1 and Th17 cells subsets

S Pianta, P Bonassi Signoroni, I Muradore… - Stem Cell Reviews and …, 2015 - Springer
We previously demonstrated that cells derived from the mesenchymal layer of the human
amniotic membrane (hAMSC) and their conditioned medium (CM-hAMSC) modulate …

The immunomodulatory properties of amniotic cells: the two sides of the coin

M Magatti, E Vertua, A Cargnoni, A Silini… - Cell …, 2018 - journals.sagepub.com
Among the many cell types useful in developing therapeutic treatments, human amniotic
cells from placenta have been proposed as valid candidates. Both human amniotic epithelial …

Human mesenchymal stem cells from adipose tissue and amnion influence T-cells depending on stimulation method and presence of other immune cells

B Kronsteiner, S Wolbank, A Peterbauer… - Stem cells and …, 2011 - liebertpub.com
Mesenchymal stem cells (MSCs) are multipotent progenitor cells exerting
immunomodulatory effects on cells of the innate and adaptive immune system. It has been …

Human amnion favours tissue repair by inducing the M1‐to‐M2 switch and enhancing M2 macrophage features

M Magatti, E Vertua, S De Munari… - Journal of tissue …, 2017 - Wiley Online Library
Human amniotic mesenchymal cells (hAMTCs) possess interesting immunomodulatory
properties, making them attractive candidates for regenerative medicine applications …