In the past two decades, significant progress has been made in the past two decades
towards the understanding of the basic mechanisms underlying cancer growth and …

The pleckstrin homology [PH] domain is a structural fold found in more than 250 proteins
making it the 11th most common domain in the human proteome. 25% of family members …

Given its critical role in T-cell signaling, interleukin-2–inducible kinase (ITK) is an appealing
therapeutic target that can contribute to the pathogenesis of certain infectious, autoimmune …

The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

Protein tyrosine kinases (PTKs) are enzymes that transfer phosphate groups to tyrosine
residues on protein substrates. Phosphorylation of proteins causes changes in their function …

In patients with underlying immunodeficiency, Epstein-Barr virus (EBV) may lead to severe
immune dysregulation manifesting as fatal mononucleosis, lymphoma, lymphoproliferative …

Recent proteomic data have uncovered an interdependence of PI3K (phosphatidylinositol 3-
kinase) and STAT3. In PI3K-transformed murine cells, STAT3 is phosphorylated on Y705 …

Interactions between the Bruton tyrosine kinase (BTK) inhibitor PCI‐32765 and the
proteasome inhibitor (bortezomib) were examined in diffuse large‐B cell lymphoma …

Acute lung injury (ALI) is linked with considerable morbidity and mortality. ALI can be caused
by various agents, one of them being sepsis. ALI is characterized by injury to vascular …

Bruton tyrosine kinase (BTK) inhibitor ibrutinib has been validated as an effective drug to
treat B cell malignancies. Combined therapies comprising ibrutinib and anti-CD20 …