Mechanisms and functions of chromosome compartmentalization
EM Hildebrand, J Dekker - Trends in biochemical sciences, 2020 - cell.com
Active and inactive chromatin are spatially separated in the nucleus. In Hi-C data, this is
reflected by the formation of compartments, whose interactions form a characteristic …
reflected by the formation of compartments, whose interactions form a characteristic …
Close to the edge: Heterochromatin at the nucleolar and nuclear peripheries
A Bizhanova, PD Kaufman - Biochimica et Biophysica Acta (BBA)-Gene …, 2021 - Elsevier
Chromatin is a dynamic structure composed of DNA, RNA, and proteins, regulating storage
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …
Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome
Organization of the genome into euchromatin and heterochromatin appears to be
evolutionarily conserved and relatively stable during lineage differentiation. In an effort to …
evolutionarily conserved and relatively stable during lineage differentiation. In an effort to …
CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention
EM Pugacheva, N Kubo, D Loukinov… - Proceedings of the …, 2020 - National Acad Sciences
The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function
together to shape chromatin architecture in mammalian cells, but the molecular details of …
together to shape chromatin architecture in mammalian cells, but the molecular details of …
HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics
Chromatin, which consists of DNA and associated proteins, contains genetic information and
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …
DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity
DNA replication timing and three-dimensional (3D) genome organization are associated
with distinct epigenome patterns across large domains. However, whether alterations in the …
with distinct epigenome patterns across large domains. However, whether alterations in the …
SPIN reveals genome-wide landscape of nuclear compartmentalization
We report SPIN, an integrative computational method to reveal genome-wide intranuclear
chromosome positioning and nuclear compartmentalization relative to multiple nuclear …
chromosome positioning and nuclear compartmentalization relative to multiple nuclear …
Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation
A hallmark of chromosome organization is the partition into transcriptionally active A and
repressed B compartments, and into topologically associating domains (TADs). Both …
repressed B compartments, and into topologically associating domains (TADs). Both …
Quantifying the phase separation property of chromatin-associated proteins under physiological conditions using an anti-1, 6-hexanediol index
Background Liquid-liquid phase separation (LLPS) is an important organizing principle for
biomolecular condensation and chromosome compartmentalization. However, while many …
biomolecular condensation and chromosome compartmentalization. However, while many …
Chromatin rigidity provides mechanical and genome protection
AD Stephens - … Research/Fundamental and Molecular Mechanisms of …, 2020 - Elsevier
The nucleus is the organelle in the cell that contains the genome and its associate proteins
which is collectively called chromatin. New work has shown that chromatin and its …
which is collectively called chromatin. New work has shown that chromatin and its …