Remodelling is a response of the myocardium and vasculature to a range of potentially
noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially …

Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …

Introduction The mechanisms that lead to cognitive impairment associated with COVID‐19
are not well understood. Methods Brain lysates from control and COVID‐19 patients were …

Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and
quality of life. Although ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle …

Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …

Oxidative stress has been suggested to play a role in the pathogenesis of atrial fibrillation
(AF). Indeed, the prevalence of AF increases with age as does oxidative stress. However …

Ca2+-dependent signaling is highly regulated in cardiomyocytes and determines the force
of cardiac muscle contraction. Ca2+ cycling refers to the release and reuptake of …

Ryanodine receptors (RyRs) and inositol 1, 4, 5‐trisphosphate receptors (IP3Rs) are
calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we …

Age-related loss of muscle mass and force (sarcopenia) contributes to disability and
increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic …

Chronic heart failure continues to impose a substantial health-care burden, despite recent
treatment advances. The key pathophysiological process that ultimately leads to chronic …