Cardiovascular remodelling in coronary artery disease and heart failure
Remodelling is a response of the myocardium and vasculature to a range of potentially
noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially …
noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially …
Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target
Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …
essential cellular functions, including cardiac and skeletal muscle contraction. The …
Alzheimer's‐like signaling in brains of COVID‐19 patients
Introduction The mechanisms that lead to cognitive impairment associated with COVID‐19
are not well understood. Methods Brain lysates from control and COVID‐19 patients were …
are not well understood. Methods Brain lysates from control and COVID‐19 patients were …
Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2
Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and
quality of life. Although ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle …
quality of life. Although ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle …
Mechanisms of Altered Ca2+ Handling in Heart Failure
M Luo, ME Anderson - Circulation research, 2013 - Am Heart Assoc
Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …
myocardium. The hallmark features of heart failure are mechanical dysfunction and …
Mitochondrial oxidative stress promotes atrial fibrillation
Oxidative stress has been suggested to play a role in the pathogenesis of atrial fibrillation
(AF). Indeed, the prevalence of AF increases with age as does oxidative stress. However …
(AF). Indeed, the prevalence of AF increases with age as does oxidative stress. However …
Calcium cycling proteins and heart failure: mechanisms and therapeutics
AR Marks - The Journal of clinical investigation, 2013 - Am Soc Clin Investig
Ca2+-dependent signaling is highly regulated in cardiomyocytes and determines the force
of cardiac muscle contraction. Ca2+ cycling refers to the release and reuptake of …
of cardiac muscle contraction. Ca2+ cycling refers to the release and reuptake of …
Intracellular calcium release channels: an update
G Santulli, R Nakashima, Q Yuan… - The Journal of …, 2017 - Wiley Online Library
Ryanodine receptors (RyRs) and inositol 1, 4, 5‐trisphosphate receptors (IP3Rs) are
calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we …
calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we …
Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging
DC Andersson, MJ Betzenhauser, S Reiken, AC Meli… - Cell metabolism, 2011 - cell.com
Age-related loss of muscle mass and force (sarcopenia) contributes to disability and
increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic …
increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic …
In search of new therapeutic targets and strategies for heart failure: recent advances in basic science
AM Shah, DL Mann - The Lancet, 2011 - thelancet.com
Chronic heart failure continues to impose a substantial health-care burden, despite recent
treatment advances. The key pathophysiological process that ultimately leads to chronic …
treatment advances. The key pathophysiological process that ultimately leads to chronic …