Stearoyl-CoA desaturase: rogue or innocent bystander?
L Hodson, BA Fielding - Progress in lipid research, 2013 - Elsevier
Different lipid fractions in humans have characteristic fatty acid profiles and these are
maintained partly through diet and to a lesser extent through endogenous synthesis. The …
maintained partly through diet and to a lesser extent through endogenous synthesis. The …
Metabolic reprogramming of the heart through stearoyl-CoA desaturase
Abstract Stearoyl-CoA desaturase (SCD), a central enzyme in lipid metabolism that
synthesizes monounsaturated fatty acids, has been linked to tissue metabolism and body …
synthesizes monounsaturated fatty acids, has been linked to tissue metabolism and body …
SCD1 alters long‐chain fatty acid (LCFA) composition and its expression is directly regulated by SREBP‐1 and PPARγ 1 in dairy goat mammary cells
D Yao, J Luo, Q He, H Shi, J Li, H Wang… - Journal of cellular …, 2017 - Wiley Online Library
Stearoyl‐CoA desaturase 1 (SCD1) is a key enzyme for the synthesis of the
monounsaturated fatty acids (MUFA) palmitoleic acid and oleic acid. In non‐ruminant …
monounsaturated fatty acids (MUFA) palmitoleic acid and oleic acid. In non‐ruminant …
Fatty acid biosynthesis and transcriptional regulation of Stearoyl-CoA Desaturase 1 (SCD1) in buffalo milk
Z Li, S Lu, K Cui, L Shafique, S Rehman, C Luo… - BMC genetics, 2020 - Springer
Background Buffalo milk is considered as a highly nutritious food owing to its higher
contents of fatty acids (FA) and rich nutrient profile. Higher fat contents of buffalo milk make it …
contents of fatty acids (FA) and rich nutrient profile. Higher fat contents of buffalo milk make it …
Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria
M Makrecka, J Kuka, K Volska, U Antone… - Molecular and cellular …, 2014 - Springer
In the heart, a nutritional state (fed or fasted) is characterized by a unique energy
metabolism pattern determined by the availability of substrates. Increased availability of …
metabolism pattern determined by the availability of substrates. Increased availability of …
Salvia miltiorrhiza and Pueraria lobata, two eminent herbs in Xin-Ke-Shu, ameliorate myocardial ischemia partially by modulating the accumulation of free fatty acids …
Abstract Background Xin-Ke-Shu (XKS), a commonly used traditional Chinese medicine,
has been clinically proven to be effective for treatment of acute myocardial ischemia (AMI) …
has been clinically proven to be effective for treatment of acute myocardial ischemia (AMI) …
Expression of lipogenic genes is upregulated in the heart with exercise training-induced but not pressure overload-induced left ventricular hypertrophy
P Dobrzyn, A Pyrkowska, MK Duda… - American Journal …, 2013 - journals.physiology.org
Cardiac hypertrophy is accompanied by molecular remodeling that affects different cellular
pathways, including fatty acid (FA) utilization. In the present study, we show that cardiac lipid …
pathways, including fatty acid (FA) utilization. In the present study, we show that cardiac lipid …
Stearoyl-CoA desaturase regulates inflammatory gene expression by changing DNA methylation level in 3T3 adipocytes
M Malodobra-Mazur, A Dziewulska, K Kozinski… - The international journal …, 2014 - Elsevier
Adipocytes are one of the primary sources of inflammatory cytokines that drive the low-grade
inflammation associated with obesity and obesity-related diseases. Stearoyl-CoA …
inflammation associated with obesity and obesity-related diseases. Stearoyl-CoA …
Metformin affects cardiac arachidonic acid metabolism and cardiac lipid metabolite storage in a prediabetic rat model
D Miklankova, I Markova, M Hüttl, I Zapletalova… - International Journal of …, 2021 - mdpi.com
Metformin can reduce cardiovascular risk independent of glycemic control. The mechanisms
behind its non-glycemic benefits, which include decreased energy intake, lower blood …
behind its non-glycemic benefits, which include decreased energy intake, lower blood …
Stearoyl-CoA desaturase 1 deficiency reduces lipid accumulation in the heart by activating lipolysis independently of peroxisome proliferator-activated receptor α
T Bednarski, A Olichwier, A Opasinska… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Abstract Stearoyl-CoA desaturase 1 (SCD1) has recently been shown to be a critical control
point in the regulation of cardiac metabolism and function. Peroxisome proliferator-activated …
point in the regulation of cardiac metabolism and function. Peroxisome proliferator-activated …