[HTML][HTML] Key recent advances in TB vaccine development and understanding of protective immune responses against Mycobacterium tuberculosis

TJ Scriba, MG Netea, AM Ginsberg - Seminars in immunology, 2020 - Elsevier
Tuberculosis is the leading infectious disease killer globally due to a single pathogen.
Despite wide deployment of standard drug regimens, modern diagnostics and a vaccine …

A century of BCG: Impact on tuberculosis control and beyond

A Ahmed, S Rakshit, V Adiga, M Dias… - Immunological …, 2021 - Wiley Online Library
BCG turns 100 this year and while it might not be the perfect vaccine, it has certainly
contributed significantly towards eradication and prevention of spread of tuberculosis (TB) …

Heterologous vaccination interventions to reduce pandemic morbidity and mortality: Modeling the US winter 2020 COVID-19 wave

N Hupert, D Marín-Hernández, B Gao… - Proceedings of the …, 2022 - National Acad Sciences
COVID-19 remains a stark health threat worldwide, in part because of minimal levels of
targeted vaccination outside high-income countries and highly transmissible variants …

BCG‐induced protection against Mycobacterium tuberculosis infection: Evidence, mechanisms, and implications for next‐generation vaccines

M Foster, PC Hill, TP Setiabudiawan… - Immunological …, 2021 - Wiley Online Library
The tuberculosis (TB) vaccine Bacillus Calmette‐Guérin (BCG) was introduced 100 years
ago, but as it provides insufficient protection against TB disease, especially in adults, new …

BCG-activation of leukocytes is sufficient for the generation of donor-independent innate anti-tumor NK and γδ T-cells that can be further expanded in vitro

G Esteso, MJ Felgueres, ÁF García-Jiménez… - …, 2023 - Taylor & Francis
ABSTRACT Bacillus Calmette-Guérin (BCG), the nonpathogenic Mycobacterium bovis strain
used as tuberculosis vaccine, has been successfully used as treatment for non-muscle …

The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity

P Ruibal, L Voogd, SA Joosten… - Immunological …, 2021 - Wiley Online Library
Vaccination strategies against mycobacteria, focusing mostly on classical T‐and B‐cells,
have shown limited success, encouraging the addition of alternative targets. Classically …

[HTML][HTML] Adolescent BCG revaccination induces a phenotypic shift in CD4+ T cell responses to Mycobacterium tuberculosis

OB Dintwe, L Ballweber Fleming, V Voillet… - Nature …, 2024 - nature.com
A recent clinical trial demonstrated that Bacille Calmette-Guérin (BCG) revaccination of
adolescents reduced the risk of sustained infection with Mycobacterium tuberculosis (M. tb) …

[HTML][HTML] Heterologous vaccine interventions: boosting immunity against future pandemics

D Marín-Hernández, DF Nixon, N Hupert - Molecular Medicine, 2021 - Springer
While vaccines traditionally have been designed and used for protection against infection or
disease caused by one specific pathogen, there are known off-target effects from vaccines …

[HTML][HTML] After 100 years of BCG immunization against tuberculosis, what is new and still outstanding for this vaccine?

MA Flores-Valdez - Vaccines, 2021 - mdpi.com
In 2021, most of the world was reasonably still concerned about the COVID-19 pandemic,
how cases were up and down in different countries, how the vaccination campaigns were …

[HTML][HTML] The quest for vaccine-induced immune correlates of protection against tuberculosis

E Nemes, A Fiore-Gartland, C Boggiano… - Vaccine …, 2022 - ncbi.nlm.nih.gov
Immunization strategies against tuberculosis (TB) that confer better protection than neonatal
vaccination with the 101-year-old Bacille Calmette-Guerin (BCG) are urgently needed to …