ATM and ATR signaling at a glance
P Awasthi, M Foiani, A Kumar - Journal of cell science, 2015 - journals.biologists.com
ABSTRACT ATM and ATR signaling pathways are well conserved throughout evolution and
are central to the maintenance of genome integrity. Although the role of both ATM and ATR …
are central to the maintenance of genome integrity. Although the role of both ATM and ATR …
Classic and variants APLs, as viewed from a therapy response
MC Geoffroy, H de Thé - Cancers, 2020 - mdpi.com
Most acute promyelocytic leukemia (APL) are caused by PML-RARA, a translocation-driven
fusion oncoprotein discovered three decades ago. Over the years, several other types of …
fusion oncoprotein discovered three decades ago. Over the years, several other types of …
Phase separation by ssDNA binding protein controlled via protein− protein and protein− DNA interactions
Bacterial single-stranded (ss) DNA-binding proteins (SSB) are essential for the replication
and maintenance of the genome. SSBs share a conserved ssDNA-binding domain, a less …
and maintenance of the genome. SSBs share a conserved ssDNA-binding domain, a less …
Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase
M Lõoke, MF Maloney, SP Bell - Genes & development, 2017 - genesdev.cshlp.org
Activation of the Mcm2–7 replicative DNA helicase is the committed step in eukaryotic DNA
replication initiation. Although Mcm2–7 activation requires binding of the helicase-activating …
replication initiation. Although Mcm2–7 activation requires binding of the helicase-activating …
ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway
Abstract The ATR-CHK1 DNA damage response pathway becomes activated by the
exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during …
exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during …
Dominant mutations in mtDNA maintenance gene SSBP1 cause optic atrophy and foveopathy
C Piro-Mégy, E Sarzi, A Tarrés-Solé… - The Journal of …, 2020 - Am Soc Clin Investig
Mutations in genes encoding components of the mitochondrial DNA (mtDNA) replication
machinery cause mtDNA depletion syndromes (MDSs), which associate ocular features with …
machinery cause mtDNA depletion syndromes (MDSs), which associate ocular features with …
Custom DNA microarrays reveal diverse binding preferences of proteins and small molecules to thousands of G-quadruplexes
Single-stranded DNA (ssDNA) containing four guanine repeats can form G-quadruplex (G4)
structures. While cellular proteins and small molecules can bind G4s, it has been difficult to …
structures. While cellular proteins and small molecules can bind G4s, it has been difficult to …
A distinct ssDNA/RNA binding interface in the Nsp9 protein from SARS‐CoV‐2
S El‐Kamand, MD Du Plessis, N Breen… - Proteins: Structure …, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a novel, highly
infectious RNA virus that belongs to the coronavirus family. Replication of the viral genome …
infectious RNA virus that belongs to the coronavirus family. Replication of the viral genome …
The anti-DNA antibodies: their specificities for unique DNA structures and their unresolved clinical impact—a system criticism and a hypothesis
OP Rekvig - Frontiers in immunology, 2022 - frontiersin.org
Systemic lupus erythematosus (SLE) is diagnosed and classified by criteria, or by
experience, intuition and traditions, and not by scientifically well-defined etiology (ies) or …
experience, intuition and traditions, and not by scientifically well-defined etiology (ies) or …
The amino acid composition of quadruplex binding proteins reveals a shared motif and predicts new potential quadruplex interactors
The importance of local DNA structures in the regulation of basic cellular processes is an
emerging field of research. Amongst local non-B DNA structures, G-quadruplexes are …
emerging field of research. Amongst local non-B DNA structures, G-quadruplexes are …