Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Physiologically, the intestinal barrier plays a crucial role in homeostasis and nutrient
absorption and prevents pathogenic entry, harmful metabolites, and endotoxin absorption …

Tumor necrosis factor (TNF) drives chronic inflammation and cell death in the intestine, and
blocking TNF is a therapeutic approach in inflammatory bowel disease (IBD). Despite this …

Immune cells must adapt to different environments during the course of an immune
response. Here we study the adaptation of CD8+ T cells to the intestinal microenvironment …

To accomplish concerted physiological reactions, nature has diversified functions of a single
hormone at at least two primary levels: 1) Different receptors recognize the same hormone …

Objective Bleeding ulcers and erosions are hallmarks of active ulcerative colitis (UC).
However, the mechanisms controlling bleeding and mucosal haemostasis remain elusive …

Background Up to 40 per cent of people with active inflammatory bowel disease (IBD) also
suffer from mood disorders such as anxiety and depression. Notwithstanding, the …

Inflammatory bowel disease (IBD) is a worldwide public health issue with an increasing
number of patients annually. However, there is no curative drug for IBD, and the present …

Osteoporosis is a common systemic disease of the skeleton, characterized by compromised
bone mass and strength, consequently leading to an increased risk of fragility fractures. In …

As a hallmark of inflammatory bowel disease (IBD), elevated intestinal epithelial cell (IEC)
death compromises the gut barrier, activating the inflammatory response and triggering …