Every cell in nature carries a rich surface coat of glycans, its glycocalyx, which constitutes
the cell's interface with its environment. In eukaryotes, the glycocalyx is composed of …

Treated glioblastoma patients survive from 6 to 14 months. In the first part of this review, we
describe glioma origins, cancer stem cells and the genomic alterations that generate …

Gangliosides (GGs), involved in malignant alteration and tumor progression/invasiveness,
are considered as tumor biomarkers or therapeutic targets. Here, we describe the first …

The release of inflammatory mediators from immune and glial cells either in the peripheral or
CNS may have an important role in the development of physiopathological processes such …

We report here on the introduction of mass spectrometry (MS) for profiling of native
gangliosides from an extracranial tumor. The analytical approach was based on a modern …

In many neuropathologies activated microglia and macrophages cause neurotoxicity and
prolong the inflammatory response. We have previously characterized the glycosphingolipid …

Glycosphingolipids comprise a lipid class characterized by the presence of sugar moieties
attached to a ceramide backbone. The role of glycosphingolipids in pathophysiology has …

Neurostatin, a natural glycosphingolipid, and NF115, a synthetic glycolipid, are inhibitors of
glioma growth. While neurostatin shows high inhibitory activity on gliomas its abundance is …

Gangliosides are sialic acid containing glycosphingolipids, commonly found on the outer
leaflet of the plasma membrane. O-acetylation of sialic acid hydroxyl groups is one of the …

The high frequency and malignancy of human glioblastomas has stimulated the search for
potential therapeutic approaches. The control of the glioma cell proliferation in response to …