Since the discovery of the RET receptor tyrosine kinase in 1985, alterations of this protein
have been found in diverse thyroid cancer subtypes. RET gene rearrangements are …

RET is a transmembrane receptor protein-tyrosine kinase that is required for the
development of the nervous system and several other tissues. The mechanism of activation …

We conducted the largest investigation of predisposition variants in cancer to date,
discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 …

RET, a single-pass receptor tyrosine kinase encoded on human chromosome 10, is well
known to the field of developmental biology for its role in the ontogenesis of the central and …

Protein phosphorylation by eukaryotic protein kinases (ePKs) is a fundamental mechanism
of cell signaling in all organisms. In model vertebrates,~ 10% of ePKs are classified as …

Rearranged during transfection (RET) is the tyrosine kinase receptor that under normal
circumstances interacts with ligand at the cell surface and mediates various essential roles …

Protein–protein interactions often regulate the activity of protein kinases by allosterically
modulating the conformation of the ATP-binding site. Bidirectional allostery implies that …

Thyroid cancer is the most frequently diagnosed endocrine malignancy, with an increasing
incidence over the last decades. The recent advances in understanding the molecular …

Parkinson's disease (PD) is a debilitating neurodegenerative disease that causes a great
clinical burden. However, its exact molecular pathologies are not fully understood. Whilst …

Deficits in axonal transport are one of the earliest pathological outcomes in several models
of amyotrophic lateral sclerosis (ALS), including SOD1G93A mice. Evidence suggests that …