The anti-viral facet of anti-rheumatic drugs: Lessons from COVID-19

C Perricone, P Triggianese, E Bartoloni, G Cafaro… - Journal of …, 2020 - Elsevier
The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection has posed the world at a pandemic risk. Coronavirus-19 disease (COVID-19) is an …

Antiviral drug resistance of human cytomegalovirus

NS Lurain, S Chou - Clinical microbiology reviews, 2010 - Am Soc Microbiol
The study of human cytomegalovirus (HCMV) antiviral drug resistance has enhanced
knowledge of the virological targets and the mechanisms of antiviral activity. The currently …

Antiviral drug resistance: mechanisms and clinical implications

L Strasfeld, S Chou - Infectious Disease Clinics, 2010 - id.theclinics.com
In the setting of intensive immunosuppression for the management of rejection in solid organ
transplant (SOT) recipients, or graft-versus-host disease (GVHD) in hematopoietic stem cell …

How I treat resistant cytomegalovirus infection in hematopoietic cell transplantation recipients

F El Chaer, DP Shah… - Blood, The Journal of the …, 2016 - ashpublications.org
Cytomegalovirus (CMV) infection is a significant complication in hematopoietic cell
transplantation (HCT) recipients. Four antiviral drugs are used for preventing or treating …

Progress and challenges in the prevention, diagnosis, and management of cytomegalovirus infection in transplantation

AP Limaye, TM Babu, M Boeckh - Clinical Microbiology Reviews, 2020 - Am Soc Microbiol
Hosts with compromised or naive immune systems, such as individuals living with HIV/AIDS,
transplant recipients, and fetuses, are at the highest risk for complications from …

New developments in the management of cytomegalovirus infection after transplantation

A Meesing, RR Razonable - Drugs, 2018 - Springer
Cytomegalovirus (CMV) continues to be one of the most important pathogens that
universally affect solid organ and allogeneic hematopoietic stem cell transplant recipients …

Kinases as potential therapeutic targets for anti-coronaviral therapy

T Pillaiyar, S Laufer - Journal of Medicinal Chemistry, 2021 - ACS Publications
The global coronavirus disease-19 (COVID-19) has affected more than 140 million and
killed more than 3 million people worldwide as of April 20, 2021. The novel human severe …

Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

HH Hoffmann, A Kunz, VA Simon… - Proceedings of the …, 2011 - National Acad Sciences
Compound A3 was identified in a high-throughput screen for inhibitors of influenza virus
replication. It displays broad-spectrum antiviral activity, and at noncytotoxic concentrations it …

On dihydroorotate dehydrogenases and their inhibitors and uses

H Munier-Lehmann, PO Vidalain… - Journal of medicinal …, 2013 - ACS Publications
Proper nucleosides availability is crucial for the proliferation of living entities (eukaryotic
cells, parasites, bacteria, and virus). Accordingly, the uses of inhibitors of the de novo …

Viral infection in the renal transplant recipient

CN Kotton, JA Fishman - Journal of the American Society of …, 2005 - journals.lww.com
Viruses are among the most common causes of opportunistic infection after transplantation
and the most important. The risk for viral infection is a function of the specific virus …