Comprehensive evidence supports that oligomerization and accumulation of amyloidogenic
Aβ42 peptides in brain is crucial in the pathogenesis of both familial and sporadic forms of …

Scientists working in the field of Alzheimer's disease and, in particular, cognitive enhancers
are very productive. The review on Drugs interacting with Enzymes was accepted in August …

A recyclable, inexpensive, non‐toxic and environmentally benign catalytic system comprised
of magnetically separable copper ferrite (CuFe2O4) nanoparticles has been developed for …

An efficient synthesis of β-aryl-β-mercapto ketones is achieved via a tandem aldol
condensation-thia-Michael addition process using an aqueous medium and diethylamine …

This paper describes the rational design, synthesis, structure-activity relationship (SAR), and
biological profile of presenilin-1 (PSEN-1) complex selective γ-secretase inhibitors …

Herein we demonstrate a novel tandem aldol condensation-thia-Michael addition process
using a bimetallic catalyst (ZrCl 4: Mg (ClO 4) 2). The novel bimetallic catalyst performs …

In the present paper, we described the design, synthesis, SAR, and biological profile of a
novel spirocyclic sulfone series of γ-secretase inhibitors (GSIs) related to MRK-560. We …

Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering
from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or …

Tricyclic sulfones were designed as γ-secretase inhibitors and found to have excellent
potency. Extensive SAR shows that a large number of sulfonamides at position 7 of the …

An exploration of the SAR of the side chain of a novel tricyclic series of γ-secretase inhibitors
led to the identification of compound (−)-16 (SCH 900229), which is a potent and PS1 …