Patient-derived and mouse endo-ectocervical organoid generation, genetic manipulation and applications to model infection

RK Gurumurthy, S Koster, N Kumar, TF Meyer… - Nature …, 2022 - nature.com
The cervix is the gateway to the upper female reproductive tract, connecting the uterus and
vagina. It plays crucial roles in fertility and pregnancy maintenance from onset until delivery …

Alterations of Vaginal Microbiota and Chlamydia trachomatis as Crucial Co-Causative Factors in Cervical Cancer Genesis Procured by HPV

C Gargiulo Isacco, MG Balzanelli, S Garzone… - Microorganisms, 2023 - mdpi.com
Chlamydia trachomatis and human papillomavirus (HPV) are the most common pathogens
found in sexually transmitted infections (STIs), and both are known to increase the risk of …

Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming

S Koster, RK Gurumurthy, N Kumar, PG Prakash… - Nature …, 2022 - nature.com
Coinfections with pathogenic microbes continually confront cervical mucosa, yet their
implications in pathogenesis remain unclear. Lack of in-vitro models recapitulating cervical …

[HTML][HTML] The role of Chlamydia trachomatis in the pathogenesis of cervical cancer

APA Franchini, B Iskander, F Anwer, F Oliveri, K Fotios… - Cureus, 2022 - ncbi.nlm.nih.gov
Chlamydia trachomatis (CT) is an obligate intracellular, Gram-negative bacterium that
causes a variety of infections in both humans and animals. It is the causative agent of one of …

[HTML][HTML] Analysis of a fractional order model for HPV and CT co-infection

UK Nwajeri, A Omame, CP Onyenegecha - Results in Physics, 2021 - Elsevier
In this work, a fractional order model for human papillomavirus (HPV) and Chlamydia
trachomatis (CT) co-infection is considered and analyzed. The existence and uniqueness of …

When Bacteria and Viruses Collide: A Tale of Chlamydia trachomatis and Sexually Transmitted Viruses

E Ghasemian, E Harding-Esch, D Mabey, MJ Holland - Viruses, 2023 - mdpi.com
The global incidence of sexually transmitted infections (STIs) remains high, with the World
Health Organization (WHO) estimating that over 1 million people acquire STIs daily. STIs …

Optimal Control and Cost-Effectiveness Analysis of an HPV–Chlamydia trachomatis Co-infection Model

A Omame, CU Nnanna, SC Inyama - Acta Biotheoretica, 2021 - Springer
In this work, a co-infection model for human papillomavirus (HPV) and Chlamydia
trachomatis with cost-effectiveness optimal control analysis is developed and analyzed. The …

A literature review on correlation between HPV coinfection with C. trachomatis and cervical neoplasia-coinfection mediated cellular transformation

S Kumari, VM Bhor - Microbial Pathogenesis, 2022 - Elsevier
Cervical cancer is the fourth most common cause of mortality worldwide. Persistent infection
with high-risk human papillomaviruses (hrHPV) is a known significant risk factor in cervical …

HPV co‐infections with other pathogens in cancer development: A comprehensive review

E Akbari, A Milani, M Seyedinkhorasani… - Journal of Medical …, 2023 - Wiley Online Library
High‐risk human papillomaviruses (HR‐HPVs) cause various malignancies in the
anogenital and oropharyngeal regions. About 70% of cervical and oropharyngeal cancers …

Human papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology

JP Mosmann, S Zayas, AX Kiguen, RF Venezuela… - BMC Infectious …, 2021 - Springer
Background HPV and C. trachomatis are the most prevalent, viral and bacterial STI
worldwide. Both commonly have an asymptomatic development and can evolve into a …