Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

Late-life depression (LLD) is one of the most common mental disorders among the older
adults. Population aging, social stress, and the COVID-19 pandemic have significantly …

Despite decades of research on the pathophysiology of depression, the development of new
therapeutic interventions has been slow, and no biomarkers of treatment response have …

Objective We investigated the association between distress symptoms (pain, fatigue,
depression, anxiety) and work impairment in four patient populations: multiple sclerosis (N …

There is growing basic and clinical evidence that major depressive disorder (MDD) is
associated with gut microbiome alterations, but clinical studies have tended not to adjust for …

Background Systemic low-grade inflammation may be a pathophysiological mechanism in a
subtype of depression. In this study we investigate a novel candidate mechanism of …

Preclinical and limited epidemiological studies suggest that oxidative stress may be
implicated in geriatric depression. Our study investigated the association between midlife …

Objective To evaluate the correlation between clinical symptoms and cognitive impairment
in elderly patients with depressive disorder. Methods In this retrospective study, a total of …

Major depressive disorder (MDD) is a mental disorder characterized by impairment in mood
regulation, loss of interest or pleasure, feelings of guilt, low self-worth, disturbed sleep and …

Introduction Despite the high prevalence of major depressive disorder (MDD) among the
elderly population, the rate of treatment is low due to stigmas and barriers to medical access …