Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as
an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in …

Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. The
primary prevention of CVD is dependent upon the ability to identify high-risk individuals long …

Introduction The purpose of this study was to compare urate-lowering (UL) efficacy and
safety of daily febuxostat and allopurinol in subjects with gout and serum urate (sUA)≥ 8.0 …

The actual reference range of serum uric acid has been assessed according to its variations
among healthy individuals. ie those without clinical evidence of gout. By this approach …

Uric acid (UA) is the end product of purine metabolism in humans due to the loss of uricase
activity by various mutations of its gene during the Miocene epoch, which led to humans …

Objective Serum uric acid (SUA) levels have been used to predict cardiovascular and all-
cause mortality event, but the data have yielded conflicting results. We investigated whether …

In recent years, there has been an increase in the prevalence of hyperuricemia, and the
latter has attracted attention as an adult lifestyle-associated disease, together with …

The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

Objective The association between hyperuricemia and cardiovascular events has been
documented in high‐risk groups, but is still undetermined in general populations, especially …

This review summarizes recent published literature on the association between serum uric
acid and cardiovascular disease, a relationship which is complex and not fully elucidated …