随着经济高速发展和工业化进程的加速, 生活方式的改变和老龄化进程的加速,
使我国糖尿病的患病率正呈快速上升的趋势, 成为继心脑血管疾病, 肿瘤之后另一个严重危害 …

Background Heterogeneity in type 2 diabetes presentation and progression suggests that
precision medicine interventions could improve clinical outcomes. We undertook a …

Moderate aLimited use in the US/Europe. bNot licensed in the US cPrescribing highly
restricted in the US; withdrawn in Europe. dNot licensed in Europe. eTo be available as a …

More than 25% of the US population aged $65 years has diabetes (1), and the aging of the
overall population is a significant driver of the diabetes epidemic. Although the burden of …

Glycaemic management in type 2 diabetes mellitus has become increasingly complex and,
to some extent, controversial, with a widening array of pharmacological agents now …

Importance In older adults with multiple serious comorbidities and functional limitations, the
harms of intensive glycemic control likely exceed the benefits. Objectives To examine …

Background Intensive glucose lowering has previously been shown to increase mortality
among persons with advanced type 2 diabetes and a high risk of cardiovascular disease …

Importance The increasing intensity of diabetes mellitus management over the past decade
may have resulted in lower rates of hyperglycemic emergencies but higher rates of hospital …

According to the most recent surveillance data, the prevalence of diabetes among US adults
over age 65 years varies from 22% to 33%, depending on the diagnostic criteria employed …

Mounting evidence suggests that there is frequently considerable variation in the risk of the
outcome of interest in clinical trial populations. These differences in risk will often cause …