Chasing molecules that were never there: misassigned natural products and the role of chemical synthesis in modern structure elucidation

KC Nicolaou, SA Snyder - Angewandte Chemie International …, 2005 - Wiley Online Library
Over the course of the past half century, the structural elucidation of unknown natural
products has undergone a tremendous revolution. Before World War II, a chemist would …

Marine natural products

JW Blunt, BR Copp, MHG Munro, PT Northcote… - Natural product …, 2005 - pubs.rsc.org
Covering: 2003. Previous review: Nat. Prod. Rep., 2004, 21, 1 This review covers the
literature published in 2003 for marine natural products, with 619 citations (413 for the …

Isolation, chemical, and biotransformation routes of labdane-type diterpenes

LMT Frija, RFM Frade, CAM Afonso - Chemical reviews, 2011 - ACS Publications
Small molecule natural products continue to provide an incomparable source of inspiration
for advances in organic chemistry and disease treatment. 1Ā6 Labdane-type diterpenes are …

Spongian diterpenoids from marine sponges

RA Keyzers, PT Northcote… - Natural Product …, 2006 - pubs.rsc.org
Covering: up to the end of 2004 This review presents the structure, biological activity and,
where applicable, references to the syntheses of 154 spongian and rearranged spongian …

Die Jagd auf Moleküle, die nie existiert haben: Falsch zugeordnete Naturstoffstrukturen und die Rolle der chemischen Synthese in der modernen Strukturaufklärung

KC Nicolaou, SA Snyder - Angewandte Chemie, 2005 - Wiley Online Library
Abstract Im Laufe der vergangenen 50 Jahre hat hinsichtlich der Aufklärung der Strukturen
unbekannter Naturstoffe eine gewaltige Umwälzung stattgefunden. In der ersten Hälfte des …

Spongiane diterpenoids

MA Gonzalez - Current bioactive compounds, 2007 - ingentaconnect.com
In this review we cover the structures, occurrence, biological activities and synthesis of all
the spongianes and rearranged spongianes since their discovery in 1974. We have given …

Short syntheses of (+)-ferruginol from (+)-dehydroabietylamine

MA González, D Pérez-Guaita - Tetrahedron, 2012 - Elsevier
Short syntheses of bioactive (+)-ferruginol in five or six synthetic steps starting from
commercially available (+)-dehydroabietylamine are described. The oxygenated function at …

Norrisolide: total synthesis and related studies

TP Brady, SH Kim, K Wen, C Kim… - … –A European Journal, 2005 - Wiley Online Library
Abstract A stereoselective synthesis of (+)‐norrisolide is presented. This natural product
belongs to a family of marine spongiane diterpenes the structure of which is characterized …

Enantio-and diastereoselective synthesis of tetrahydrofuro [2, 3-b] furan-2 (3H)-one derivatives and related oxygen heterocycles via an asymmetric organocatalytic …

WW Zhao, YK Liu - Organic Chemistry Frontiers, 2017 - pubs.rsc.org
Tetrahydrofuro [2, 3-b] furan-2 (3H)-one derivatives bearing four stereogenic centers were
achieved via an asymmetric organocatalytic cascade process with excellent stereoselectivity …

Divergent synthesis and chemical reactivity of bicyclic lactone fragments of complex rearranged spongian diterpenes

MJ Schnermann, CM Beaudry… - Journal of the …, 2011 - ACS Publications
The synthesis and direct comparison of the chemical reactivity of the two highly oxidized
bicyclic lactone fragments found in rearranged spongian diterpenes (8-substituted 6-acetoxy …