Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
Chemogenetic modulation of accumbens direct or indirect pathways bidirectionally alters reinstatement of heroin-seeking in high-but not low-risk rats
TJ O'Neal, MN Nooney, K Thien… - …, 2020 - nature.com
Opioid addiction has been declared a public health emergency, with fatal overdoses
following relapse reaching epidemic proportions and disease-associated costs continuing to …
following relapse reaching epidemic proportions and disease-associated costs continuing to …
Ventral pallidum neurons encode incentive value and promote cue-elicited instrumental actions
The ventral pallidum (VP) is posited to contribute to reward seeking by conveying upstream
signals from the nucleus accumbens (NAc). Yet, very little is known about how VP neuron …
signals from the nucleus accumbens (NAc). Yet, very little is known about how VP neuron …
The mesolimbic dopamine activity signatures of relapse to alcohol-seeking
The mesolimbic dopamine system comprises distinct compartments supporting different
functions in learning and motivation. Less well understood is how complex addiction-related …
functions in learning and motivation. Less well understood is how complex addiction-related …
Context-induced relapse after extinction versus punishment: similarities and differences
Results from clinical studies suggest that drug relapse and craving are often provoked by
exposure to drug-associated contexts. Since 2002, this phenomenon has been modeled in …
exposure to drug-associated contexts. Since 2002, this phenomenon has been modeled in …
Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons
Context-induced reinstatement of drug seeking is a well established animal model for
assessing the neural mechanisms underlying context-induced drug relapse, a major factor …
assessing the neural mechanisms underlying context-induced drug relapse, a major factor …
Role of corticostriatal circuits in context-induced reinstatement of drug seeking
Drug addiction is characterized by persistent relapse vulnerability during abstinence. In
abstinent drug users, relapse is often precipitated by re-exposure to environmental contexts …
abstinent drug users, relapse is often precipitated by re-exposure to environmental contexts …
The role of enkephalinergic systems in substance use disorders
LG Rysztak, EM Jutkiewicz - Frontiers in Systems Neuroscience, 2022 - frontiersin.org
Enkephalin, an endogenous opioid peptide, is highly expressed in the reward pathway and
may modulate neurotransmission to regulate reward-related behaviors, such as drug-taking …
may modulate neurotransmission to regulate reward-related behaviors, such as drug-taking …
Regulation of alcohol extinction and cue-induced reinstatement by specific projections among medial prefrontal cortex, nucleus accumbens, and basolateral …
CR Keistler, E Hammarlund, JM Barker… - Journal of …, 2017 - Soc Neuroscience
The ability to inhibit drinking is a significant challenge for recovering alcoholics, especially in
the presence of alcohol-associated cues. Previous studies have demonstrated that the …
the presence of alcohol-associated cues. Previous studies have demonstrated that the …
Endogenous opiates and behavior: 2013
RJ Bodnar - Peptides, 2014 - Elsevier
This paper is the thirty-sixth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2013 …
concerning the endogenous opioid system. It summarizes papers published during 2013 …