Alzheimer's disease: Recent treatment strategies
M Vaz, S Silvestre - European journal of pharmacology, 2020 - Elsevier
Alzheimer Disease (AD) is a neurodegenerative disease characterized by two
neuropathological hallmarks: extracellular deposition of amyloid plaques and intracellular …
neuropathological hallmarks: extracellular deposition of amyloid plaques and intracellular …
Tau-targeting therapies for Alzheimer disease
EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
Current state of Alzheimer's fluid biomarkers
JL Molinuevo, S Ayton, R Batrla, MM Bednar… - Acta …, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …
heterogeneous pathophysiology. The number of people living with AD is predicted to …
Tau in physiology and pathology
Y Wang, E Mandelkow - Nature reviews neuroscience, 2016 - nature.com
Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …
Practical considerations for choosing a mouse model of Alzheimer's disease
JL Jankowsky, H Zheng - Molecular neurodegeneration, 2017 - Springer
Alzheimer's disease (AD) is behaviorally identified by progressive memory impairment and
pathologically characterized by the triad of β-amyloid plaques, neurofibrillary tangles, and …
pathologically characterized by the triad of β-amyloid plaques, neurofibrillary tangles, and …
Role of tau protein in Alzheimer's disease: The prime pathological player
Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …
A review on Alzheimer's disease pathophysiology and its management: an update
Alzheimer's disease acknowledged as progressive multifarious neurodegenerative disorder,
is the leading cause of dementia in late adult life. Pathologically it is characterized by …
is the leading cause of dementia in late adult life. Pathologically it is characterized by …
Neurotoxicity in acute and repeated organophosphate exposure
SX Naughton, AV Terry Jr - Toxicology, 2018 - Elsevier
The term organophosphate (OP) refers to a diverse group of chemicals that are found in
hundreds of products worldwide. As pesticides, their most common use, OPs are clearly …
hundreds of products worldwide. As pesticides, their most common use, OPs are clearly …
[HTML][HTML] Enhancing autophagy in Alzheimer's disease through drug repositioning
Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …
aging of the global population. Unfortunately, drugs for treating AD have been largely …
[HTML][HTML] Consciousness in the universe: A review of the 'Orch OR'theory
S Hameroff, R Penrose - Physics of life reviews, 2014 - Elsevier
The nature of consciousness, the mechanism by which it occurs in the brain, and its ultimate
place in the universe are unknown. We proposed in the mid 1990's that consciousness …
place in the universe are unknown. We proposed in the mid 1990's that consciousness …