Mimicking the extracellular world: From natural to fully synthetic matrices utilizing supramolecular biomaterials
The extracellular matrix (ECM) has evolved around complex covalent and non-covalent
interactions to create impressive function—from cellular signaling to constant remodeling. A …
interactions to create impressive function—from cellular signaling to constant remodeling. A …
Synthetic, multi-dynamic hydrogels by uniting stress-stiffening and supramolecular polymers
Nature uses discrete molecular building blocks to form polymers that assemble into
multicomponent, multi-dynamic networks, inside (cytoskeleton) and outside (extracellular …
multicomponent, multi-dynamic networks, inside (cytoskeleton) and outside (extracellular …
Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel–Cell Interactions
Hydrogels have emerged as a promising class of extracellular matrix (ECM)-mimicking
materials in regenerative medicine. Here, we briefly describe current state-of-the-art of ECM …
materials in regenerative medicine. Here, we briefly describe current state-of-the-art of ECM …
Co‐Assembled Supramolecular Hydrogelators Enhance Glomerulogenesis in Kidney Organoids Through Cell‐Adhesive Motifs
JF van Sprang, JGM Aarts, MGTA Rutten… - Advanced Functional …, 2024 - Wiley Online Library
Soluble biochemical agents are being employed to generate kidney organoids from human‐
induced pluripotent stem cells. However, this soluble factor approach does not consider the …
induced pluripotent stem cells. However, this soluble factor approach does not consider the …
Molecularly Engineered Supramolecular Thermoresponsive Hydrogels with Tunable Mechanical and Dynamic Properties
Synthetic supramolecular polymers and hydrogels in water are emerging as promising
biomaterials due to their modularity and intrinsic dynamics. Here, we introduce temperature …
biomaterials due to their modularity and intrinsic dynamics. Here, we introduce temperature …
Investigating the self-assembly of 2NapFF and ureido-pyrimidinone multicomponent systems for cell culture
CM Wallace, MM Rovers, R Bellan… - Journal of Materials …, 2024 - pubs.rsc.org
Low molecular weight gels are formed via the self-assembly of small molecules into fibrous
structures. In the case of hydrogels, these networks entrap large volumes of water, yielding …
structures. In the case of hydrogels, these networks entrap large volumes of water, yielding …
Improving the bioactivity and mechanical properties of poly (ethylene glycol)-based hydrogels through a supramolecular support network
Y Liu, S Islam, A Bakker, Z Li, A Ajam… - Journal of Materials …, 2025 - pubs.rsc.org
Most synthetic hydrogels are formed through radical polymerization to yield a homogenous
covalent meshwork. In contrast, natural hydrogels form through mechanisms involving both …
covalent meshwork. In contrast, natural hydrogels form through mechanisms involving both …