Mimicking the extracellular world: From natural to fully synthetic matrices utilizing supramolecular biomaterials

L Rijns, M Rutten, A Vrehen, A Aldana, M Baker… - Nanoscale, 2024 - pubs.rsc.org
The extracellular matrix (ECM) has evolved around complex covalent and non-covalent
interactions to create impressive function—from cellular signaling to constant remodeling. A …

Synthetic, multi-dynamic hydrogels by uniting stress-stiffening and supramolecular polymers

L Rijns, MGTA Rutten, R Bellan, H Yuan… - Science …, 2024 - science.org
Nature uses discrete molecular building blocks to form polymers that assemble into
multicomponent, multi-dynamic networks, inside (cytoskeleton) and outside (extracellular …

Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel–Cell Interactions

L Rijns, MB Baker, PYW Dankers - Journal of the American …, 2024 - ACS Publications
Hydrogels have emerged as a promising class of extracellular matrix (ECM)-mimicking
materials in regenerative medicine. Here, we briefly describe current state-of-the-art of ECM …

Co‐Assembled Supramolecular Hydrogelators Enhance Glomerulogenesis in Kidney Organoids Through Cell‐Adhesive Motifs

JF van Sprang, JGM Aarts, MGTA Rutten… - Advanced Functional …, 2024 - Wiley Online Library
Soluble biochemical agents are being employed to generate kidney organoids from human‐
induced pluripotent stem cells. However, this soluble factor approach does not consider the …

Molecularly Engineered Supramolecular Thermoresponsive Hydrogels with Tunable Mechanical and Dynamic Properties

L Rijns, H Duijs, RPM Lafleur, R Cardinaels… - …, 2024 - ACS Publications
Synthetic supramolecular polymers and hydrogels in water are emerging as promising
biomaterials due to their modularity and intrinsic dynamics. Here, we introduce temperature …

Investigating the self-assembly of 2NapFF and ureido-pyrimidinone multicomponent systems for cell culture

CM Wallace, MM Rovers, R Bellan… - Journal of Materials …, 2024 - pubs.rsc.org
Low molecular weight gels are formed via the self-assembly of small molecules into fibrous
structures. In the case of hydrogels, these networks entrap large volumes of water, yielding …

Improving the bioactivity and mechanical properties of poly (ethylene glycol)-based hydrogels through a supramolecular support network

Y Liu, S Islam, A Bakker, Z Li, A Ajam… - Journal of Materials …, 2025 - pubs.rsc.org
Most synthetic hydrogels are formed through radical polymerization to yield a homogenous
covalent meshwork. In contrast, natural hydrogels form through mechanisms involving both …