Uterine carcinosarcoma (UCS) is a biphasic aggressive high-grade endometrial cancer in
which the sarcoma element has de-differentiated from the carcinoma element. UCS is …

Although endometrial cancer management remains challenging, a deeper understanding of
the genetic diversity as well as the drivers of the various pathogenic states of this disease …

FOXA2 encodes a transcription factor mutated in 10% of endometrial cancers (ECs), with a
higher mutation rate in aggressive variants. FOXA2 has essential roles in embryonic and …

Cancer is instigated by mutator phenotypes, including deficient mismatch repair and p53-
associated chromosomal instability. More recently, a distinct class of cancers was identified …

FBXW7, which encodes a substrate‐specific receptor of an SCF E3 ligase complex, is a
frequently mutated human tumor suppressor gene known to regulate the post‐translational …

The F-Box and WD Repeat Domain Containing 7 (FBXW7) protein has been shown to
regulate cellular growth and act as a tumor suppressor. This protein, also known as FBW7 …

Uterine carcinosarcoma (UCS), also known as malignant mixed Müllerian tumor, is a rare
gynecological malignancy characterized by poor prognosis. This “biphasic” neoplasm …

High‐risk endometrial cancer has poor prognosis and is increasing in incidence. However,
understanding of the molecular mechanisms which drive this disease is limited. We used …

TP53 and ARID1A are frequently mutated across cancer but rarely in the same primary
tumor. Endometrial cancer has the highest TP53-ARID1A mutual exclusivity rate. However …

Endometrial polyps (EMPs) are common exophytic masses associated with abnormal
uterine bleeding and infertility. Unlike normal endometrium, which is cyclically shed, EMPs …