Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …

Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …

Enzyme function annotation is a fundamental challenge, and numerous computational tools
have been developed. However, most of these tools cannot accurately predict functional …

The enzymatic generation of carbon–halogen bonds is a powerful strategy used by both
nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of …

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

Despite a long and distinguished history focused on the isolation and structural elucidation
of secondary metabolites from all classes of organisms, organic chemists have only securely …

Carbohydrate diversity is foundational in the molecular literacy that regulates cellular
function and communication. Consequently, delineating and leveraging this structure …

Halogenated molecules are widely distributed in the biosphere. A variety of halogenated
aromatic and aliphatic compounds are man-made and can be harmful to the environment …

In nature, halogenation is a strategy used to increase the biological activity of secondary
metabolites, compounds that are often effective as drugs. However, halides are not …

Fluorinases, the only enzymes known to catalyze the transfer of fluorine to an organic
molecule, are essential catalysts for the biological synthesis of valuable organofluorines …