B cell abnormalities in systemic lupus erythematosus and lupus nephritis—role in pathogenesis and effect of immunosuppressive treatments
Abnormalities in B cells play pivotal roles in the pathogenesis of systemic lupus
erythematosus (SLE) and lupus nephritis (LN). Breach in central and peripheral tolerance …
erythematosus (SLE) and lupus nephritis (LN). Breach in central and peripheral tolerance …
[HTML][HTML] Clinical disease activity and flare in SLE: Current concepts and novel biomarkers
A Thanou, E Jupe, M Purushothaman, TB Niewold… - Journal of …, 2021 - Elsevier
Systemic lupus erythematosus (SLE) is a complex and heterogeneous systemic
autoimmune disease associated with innate and adaptive immune dysregulation. SLE …
autoimmune disease associated with innate and adaptive immune dysregulation. SLE …
T cells and autoimmune kidney disease
A Suarez-Fueyo, SJ Bradley, D Klatzmann… - Nature Reviews …, 2017 - nature.com
Glomerulonephritis is traditionally considered to result from the invasion of the kidney by
autoantibodies and immune complexes from the circulation or following their formation in …
autoantibodies and immune complexes from the circulation or following their formation in …
Long-term outcomes with rituximab as add-on therapy in severe childhood-onset lupus nephritis
EY Chan, S Wong, FF Lai, T Ho, P Tong, W Lai… - Pediatric …, 2023 - Springer
Background Long-term data pertaining to rituximab as add-on therapy in childhood-onset
lupus nephritis (cLN) is scarce. Methods A retrospective cohort study was conducted on all …
lupus nephritis (cLN) is scarce. Methods A retrospective cohort study was conducted on all …
Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome
X Peng, T Yang, G Liu, H Liu, Y Peng, L He - International …, 2018 - Elsevier
Background Lupus nephritis (LN) is a leading cause of mortality. The activation of NLRP3
inflammasome contributed to LN development and thus became a therapeutic target. Here …
inflammasome contributed to LN development and thus became a therapeutic target. Here …
Genetics of lupus nephritis: clinical implications
ME Munroe, JA James - Seminars in nephrology, 2015 - Elsevier
Systemic lupus erythematosus is a heterogeneous autoimmune disease marked by the
presence of pathogenic autoantibodies, immune dysregulation, and chronic inflammation …
presence of pathogenic autoantibodies, immune dysregulation, and chronic inflammation …
[HTML][HTML] Renal NLRP3 Inflammasome activation is associated with disease activity in lupus nephritis
F Chen, X Liu, J Tao, Z Mao, H Wang, Y Tan, Z Qu… - Clinical …, 2023 - Elsevier
The current study was initiated to comprehensively evaluate renal NLRP3 inflammasome
pathway activation in lupus nephritis (LN) patients and their clinicopathological significances …
pathway activation in lupus nephritis (LN) patients and their clinicopathological significances …
Autoimmune thyroiditis and glomerulopathies
D Santoro, C Vadalà, R Siligato, M Buemi… - Frontiers in …, 2017 - frontiersin.org
Autoimmune thyroiditis (AIT) is generally associated with hypothyroidism. It affects~ 2% of
the female population and 0.2% of the male population. The evidence of thyroid function …
the female population and 0.2% of the male population. The evidence of thyroid function …
Relevant genetic polymorphisms and kidney expression of Toll-like receptor (TLR)-5 and TLR-9 in lupus nephritis
N Elloumi, R Fakhfakh, O Abida, L Ayadi… - Clinical & …, 2017 - academic.oup.com
Toll-like receptor (TLR) genetic polymorphisms may modify their expression causing
inflammatory disorders and influencing both susceptibility and severity of lupus …
inflammatory disorders and influencing both susceptibility and severity of lupus …
Reduced activated regulatory T cells and imbalance of Th17/activated Treg cells marks renal involvement in ANCA-associated vasculitis
Y Wang, S Zhang, N Zhang, M Feng, Z Liang… - Molecular …, 2020 - Elsevier
The role of naturally occurring regulatory T cells (Treg) in the control of the immune
tolerance of ANCA-associated vasculitis (AAV) has not been well defined. Therefore, we …
tolerance of ANCA-associated vasculitis (AAV) has not been well defined. Therefore, we …