Abnormalities in B cells play pivotal roles in the pathogenesis of systemic lupus
erythematosus (SLE) and lupus nephritis (LN). Breach in central and peripheral tolerance …

Systemic lupus erythematosus (SLE) is a complex and heterogeneous systemic
autoimmune disease associated with innate and adaptive immune dysregulation. SLE …

Glomerulonephritis is traditionally considered to result from the invasion of the kidney by
autoantibodies and immune complexes from the circulation or following their formation in …

Background Long-term data pertaining to rituximab as add-on therapy in childhood-onset
lupus nephritis (cLN) is scarce. Methods A retrospective cohort study was conducted on all …

Background Lupus nephritis (LN) is a leading cause of mortality. The activation of NLRP3
inflammasome contributed to LN development and thus became a therapeutic target. Here …

Systemic lupus erythematosus is a heterogeneous autoimmune disease marked by the
presence of pathogenic autoantibodies, immune dysregulation, and chronic inflammation …

The current study was initiated to comprehensively evaluate renal NLRP3 inflammasome
pathway activation in lupus nephritis (LN) patients and their clinicopathological significances …

Autoimmune thyroiditis (AIT) is generally associated with hypothyroidism. It affects~ 2% of
the female population and 0.2% of the male population. The evidence of thyroid function …

Toll-like receptor (TLR) genetic polymorphisms may modify their expression causing
inflammatory disorders and influencing both susceptibility and severity of lupus …

The role of naturally occurring regulatory T cells (Treg) in the control of the immune
tolerance of ANCA-associated vasculitis (AAV) has not been well defined. Therefore, we …