The approval of the first small interfering RNA (siRNA) drug Patisiran by FDA in 2018 marks
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …

miRNAs are small non-coding RNAs (ncRNAs), which regulate gene expression. Here, the
authors describe the contribution of miRNAs to cardiac biology and disease. They discuss …

Abnormal mitochondrial fission participates in the pathogenesis of many diseases. Long non-
coding RNAs (lncRNAs) are emerging as new players in gene regulation, but how lncRNAs …

Every year more than 13 million deaths worldwide are due to environmental pollutants, and
approximately 24% of diseases are caused by environmental exposures that might be …

MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression in most
biological processes. They act by guiding the RNAi-induced silencing complex (RISC) to …

Rationale: Mammalian cardiomyocytes withdraw from the cell cycle during early postnatal
development, which significantly limits the capacity of the adult mammalian heart to …

Mitochondrial morphology is crucial for tissue homeostasis, but its role in cell differentiation
is unclear. We found that mitochondrial fusion was required for proper cardiomyocyte …

Recent findings demonstrated the importance of microRNAs (miRNAs) in the vasculature
and the orchestration of lipid metabolism and glucose homeostasis. MiRNA networks …

The vast majority of mammalian DNA does not encode for proteins but instead is transcribed
into noncoding (nc) RNAs having diverse regulatory functions. The poorly characterized …

Pollution is a major issue impacting the health of life and ecosystems. In particular, some
pollutants may alter gene expression by epigenetic mechanisms such as deoxyribonucleic …