African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping

MC Campbell, SA Tishkoff - Annu. Rev. Genomics Hum. Genet., 2008 - annualreviews.org
Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

Host genes associated with HIV/AIDS: advances in gene discovery

P An, CA Winkler - Trends in genetics, 2010 - cell.com
Twenty-five years after the discovery of HIV as the cause of AIDS there is still no effective
vaccine and no cure for this disease. HIV susceptibility shows a substantial degree of …

Phenotypic properties of transmitted founder HIV-1

NF Parrish, F Gao, H Li, EE Giorgi… - Proceedings of the …, 2013 - National Acad Sciences
Defining the virus–host interactions responsible for HIV-1 transmission, including the
phenotypic requirements of viruses capable of establishing de novo infections, could be …

Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals

L Luo, W Liang, J Pang, G Xu, Y Chen, X Guo, X Wang… - Cell discovery, 2021 - nature.com
SARS-CoV-2 outbreak has been declared by World Health Organization as a worldwide
pandemic. However, there are many unknowns about the antigen-specific T-cell-mediated …

Severe dengue prognosis using human genome data and machine learning

C Davi, A Pastor, T Oliveira… - IEEE Transactions …, 2019 - ieeexplore.ieee.org
Dengue has become one of the most important worldwide arthropod-borne diseases.
Dengue phenotypes are based on laboratorial and clinical exams, which are known to be …

[HTML][HTML] A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers

J Lajoie, J Juno, A Burgener, S Rahman, K Mogk… - Mucosal …, 2012 - Elsevier
The predominance of HIV-1 sexual transmission requires a greater understanding of the
interaction between HIV-1 and the mucosal immune system. The study of HIV-1-exposed …

[HTML][HTML] Recent insights into the HIV/AIDS pandemic

JC Becerra, LS Bildstein, JS Gach - Microbial cell, 2016 - ncbi.nlm.nih.gov
Etiology, transmission and protection: Transmission of HIV, the causative agent of AIDS,
occurs predominantly through bodily fluids. Factors that significantly alter the risk of HIV …

Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls

PJ McLaren, C Coulonges, S Ripke… - PLoS …, 2013 - journals.plos.org
Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected
individuals, identifying common genetic influences on viral control and disease course …

HIV-Exposed Seronegative Commercial Sex Workers Show a Quiescent Phenotype in the CD4+ T Cell Compartment and Reduced Expression of HIV-Dependent …

PJ McLaren, T Blake Ball, C Wachihi… - The Journal of …, 2010 - academic.oup.com
Studies of human immunodeficiency virus (HIV)-exposed seronegative individuals are
crucial to inform vaccine design. In the present study we demonstrated that HIV-exposed …

HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production

AN Harman, J Lai, S Turville… - Blood, The Journal …, 2011 - ashpublications.org
Many viruses have developed mechanisms to evade the IFN response. Here, HIV-1 was
shown to induce a distinct subset of IFN-stimulated genes (ISGs) in monocyte-derived …