Despite all clinical progress recorded in the last decades, human breast cancer (HBC)
remains a major challenge worldwide both in terms of its incidence and its management …

α-Mangostin (AMG) is a potent anticancer xanthone that was discovered in mangosteen
(Garcinia mangostana Linn.). AMG possesses the highest opportunity for chemopreventive …

Toosendanin (TSN) and isotoosendanin (ITSN) are two natural triterpenoids isolated from
Fructus Meliae Toosendan or Cortex Meliae. This study aims to observe the inhibition of …

Aims Breast cancer (BC) presents high mortality rate and about 25–46% have mutation in
the PIK3CA gene. Alpelisib is a PI3K inhibitor that acts on p110α, which is a subunit of the …

Actein is a natural triterpenoid glycoside, isolated from the rhizomes of Cimicifuga foetida,
which have been demonstrated to be potential in the treatment of breast cancer previously …

Simple Summary Breast cancer (BC) has common characteristics in women and female
dogs, such as high recurrence, metastasis, and mortality rate. In both species, BC prognosis …

Triple-negative breast cancer is a sub-type of clinically and molecularly heterogeneous
malignant disease with a worse prognosis and earlier recurrence than HER2-amplified or …

Co-delivery of epothilone B (EpoB) and rapamycin (Rap) increases cytotoxicity against
various kinds of cancers. However, the current challenge is to develop a drug delivery …

Toosendanin (TSN) is a natural anti-cancer compound that is isolated from the traditional
Chinese herbal Melia toosendan Sieb et Zucc. However, the research effect of TSN in the …

Introduction Single-cell RNA sequencing (scRNA-seq) has become an essential tool for
uncovering the complexities of various physiological and immunopathological conditions in …