Liver allograft rejection remains a significant cause of morbidity and graft failure in liver
transplant recipients. Rejection is caused by the recognition of non-self donor alloantigens …

The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that
binds to LFA3, a cell surface protein expressed on eg, antigen-presenting cells. CD2 has an …

The use of chimeric antigen receptor (CAR)-engineered regulatory T cells (Tregs) has
emerged as a promising strategy to promote immune tolerance. However, in conventional T …

Regulatory T (Treg) cells that express the transcription factor forkhead box protein P3
(FOXP3) are naturally present in the immune system and have roles in the maintenance of …

B‐cell receptors and T‐cell receptors are the key molecules responsible for specific antigen
recognition in adaptive immunity. The huge diversity of immune receptor repertoires …

Kidney transplantation is the most common solid organ transplant and the best current
therapy for end-stage kidney failure. However, with standard immunosuppression, most …

Background: Acute kidney injury (AKI) remains a major global public health concern due to
its high morbidity and mortality. The progression from AKI to chronic kidney disease (CKD) …

We recently developed a high throughput T cell receptor β chain (TCRβ) sequencing-based
approach to identifying and tracking donor-reactive T cells. To address the role of clonal …

Intragraft events thought to be relevant to the development of tolerance are here subjected to
a comprehensive mechanistic study during long‐term spontaneous tolerance that occurs in …

Liver transplantation (LTx) is currently the most powerful treatment for end-stage liver
disease. Although liver allograft is more tolerogenic compared to other solid organs, the …