The immunological basis of liver allograft rejection
Liver allograft rejection remains a significant cause of morbidity and graft failure in liver
transplant recipients. Rejection is caused by the recognition of non-self donor alloantigens …
transplant recipients. Rejection is caused by the recognition of non-self donor alloantigens …
CD2 immunobiology
C Binder, F Cvetkovski, F Sellberg, S Berg… - Frontiers in …, 2020 - frontiersin.org
The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that
binds to LFA3, a cell surface protein expressed on eg, antigen-presenting cells. CD2 has an …
binds to LFA3, a cell surface protein expressed on eg, antigen-presenting cells. CD2 has an …
Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
B Lamarthée, A Marchal, S Charbonnier, T Blein… - Nature …, 2021 - nature.com
The use of chimeric antigen receptor (CAR)-engineered regulatory T cells (Tregs) has
emerged as a promising strategy to promote immune tolerance. However, in conventional T …
emerged as a promising strategy to promote immune tolerance. However, in conventional T …
Regulatory T cells in autoimmune kidney diseases and transplantation
N Mikami, S Sakaguchi - Nature Reviews Nephrology, 2023 - nature.com
Regulatory T (Treg) cells that express the transcription factor forkhead box protein P3
(FOXP3) are naturally present in the immune system and have roles in the maintenance of …
(FOXP3) are naturally present in the immune system and have roles in the maintenance of …
T‐cell receptor and B‐cell receptor repertoire profiling in adaptive immunity
A Minervina, M Pogorelyy… - Transplant International, 2019 - Wiley Online Library
B‐cell receptors and T‐cell receptors are the key molecules responsible for specific antigen
recognition in adaptive immunity. The huge diversity of immune receptor repertoires …
recognition in adaptive immunity. The huge diversity of immune receptor repertoires …
Antigen specific regulatory T cells in kidney transplantation and other tolerance settings
Kidney transplantation is the most common solid organ transplant and the best current
therapy for end-stage kidney failure. However, with standard immunosuppression, most …
therapy for end-stage kidney failure. However, with standard immunosuppression, most …
Lymphocytes: versatile participants in acute kidney injury and progression to chronic kidney disease
C Cao, Y Yao, R Zeng - Frontiers in Physiology, 2021 - frontiersin.org
Background: Acute kidney injury (AKI) remains a major global public health concern due to
its high morbidity and mortality. The progression from AKI to chronic kidney disease (CKD) …
its high morbidity and mortality. The progression from AKI to chronic kidney disease (CKD) …
[HTML][HTML] Deletion of donor-reactive T cell clones after human liver transplant
TM Savage, BA Shonts, S Lau, A Obradovic… - American Journal of …, 2020 - Elsevier
We recently developed a high throughput T cell receptor β chain (TCRβ) sequencing-based
approach to identifying and tracking donor-reactive T cells. To address the role of clonal …
approach to identifying and tracking donor-reactive T cells. To address the role of clonal …
Novel intragraft regulatory lymphoid structures in kidney allograft tolerance
IA Rosales, C Yang, EA Farkash… - American Journal of …, 2022 - Wiley Online Library
Intragraft events thought to be relevant to the development of tolerance are here subjected to
a comprehensive mechanistic study during long‐term spontaneous tolerance that occurs in …
a comprehensive mechanistic study during long‐term spontaneous tolerance that occurs in …
Mechanisms of immune tolerance in liver transplantation-crosstalk between alloreactive T cells and liver cells with therapeutic prospects
Liver transplantation (LTx) is currently the most powerful treatment for end-stage liver
disease. Although liver allograft is more tolerogenic compared to other solid organs, the …
disease. Although liver allograft is more tolerogenic compared to other solid organs, the …