First-in-human prospective trial of sonobiopsy in high-grade glioma patients using neuronavigation-guided focused ultrasound

J Yuan, L Xu, CY Chien, Y Yang, Y Yue… - NPJ Precision …, 2023 - nature.com
Sonobiopsy is an emerging technology that combines focused ultrasound (FUS) with
microbubbles to enrich circulating brain disease-specific biomarkers for noninvasive …

[HTML][HTML] Ultrasound neuromodulation: planning and validating treatments

MK Sigona, CF Caskey - Current Opinion in Behavioral Sciences, 2024 - Elsevier
Highlights•Pre-print discusses biophysical safety in transcranial focused
ultrasound.•Identifies thermal and mechanical risks in focused ultrasound.• …

[HTML][HTML] The effect of transcranial ultrasound pulse repetition frequency on sustained inhibition in the human primary motor cortex: A double-blind, sham-controlled …

AK Zadeh, H Raghuram, S Shrestha, M Kibreab… - Brain Stimulation, 2024 - Elsevier
Background Non-invasive brain stimulation techniques such as transcranial magnetic
stimulation and transcranial direct current stimulation hold promise for inducing brain …

Small volume blood-brain barrier opening in macaques with a 1 MHz ultrasound phased array

TJ Manuel, MK Sigona, MA Phipps, J Kusunose… - Journal of Controlled …, 2023 - Elsevier
The use of focused ultrasound to open the blood-brain barrier (BBB) has the potential to
deliver drugs to specific regions of the brain. The size of the BBB opening and ability to …

Potential of sonobiopsy as a novel diagnosis tool for brain cancer

L Yan, K Fu, L Li, Q Li, X Zhou - Molecular Therapy Oncology, 2024 - cell.com
Brain tumors have a poor prognosis. Early, accurate diagnosis and treatment are crucial.
Although brain surgical biopsy can provide an accurate diagnosis, it is highly invasive and …

First-in-human prospective trial of sonobiopsy in glioblastoma patients using neuronavigation-guided focused ultrasound

J Yuan, L Xu, CY Chien, Y Yang, Y Yue, S Fadera… - medRxiv, 2023 - medrxiv.org
Sonobiopsy is an emerging technology that combines focused ultrasound (FUS) with
microbubbles to enrich circulating brain disease-specific biomarkers for noninvasive …

BabelBrain: An Open-Source Application for Prospective Modeling of Transcranial Focused Ultrasound for Neuromodulation Applications

S Pichardo - IEEE Transactions on Ultrasonics, Ferroelectrics …, 2023 - ieeexplore.ieee.org
BabelBrain is an open-source standalone graphic-user-interface application designed for
studies of neuromodulation using transcranial-focused ultrasound (FUS). It calculates the …

Quality assurance for focused ultrasound-induced blood-brain barrier opening procedure using passive acoustic detection

CY Chien, L Xu, J Yuan, S Fadera, AH Stark… - …, 2024 - thelancet.com
Background Focused ultrasound (FUS) combined with microbubbles is a promising
technique for noninvasive, reversible, and spatially targeted blood-brain barrier opening …

Practical targeting errors during optically tracked transcranial focused ultrasound using MR-ARFI and array-based steering

MA Phipps, TJ Manuel, MK Sigona… - IEEE Transactions …, 2024 - ieeexplore.ieee.org
Objective: Transcranial focused ultrasound (tFUS) is being explored for neuroscience
research and clinical applications due to its ability to affect precise brain regions …

Design and validation of a patient-specific stereotactic frame for transcranial ultrasound therapy

J Kusunose, WJ Rodriguez, H Luo… - IEEE Transactions …, 2024 - ieeexplore.ieee.org
Transcranial focused ultrasound (tFUS) procedures such as neuromodulation and blood
brain barrier opening require precise focus placement within the brain. MRI is currently the …