How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
Biphasic amplitude oscillator characterized by distinct dynamics of trough and crest
Biphasic amplitude dynamics (BAD) of oscillation have been observed in many biological
systems. However, the specific topology structure and regulatory mechanisms underlying …
systems. However, the specific topology structure and regulatory mechanisms underlying …
Para-chloro-meta-xylenol reshaped the fates of antibiotic resistance genes during sludge fermentation: Insights of cell membrane permeability, bacterial structure and …
W Du, T Wang, F Wang, Z Li, W Huang, J Tai… - Science of The Total …, 2022 - Elsevier
The occurrence of para-chloro-meta-xylenol (PCMX, as largely consumed antimicrobial
chemicals) in waste activated sludge (WAS) would pose environmental risks for WAS …
chemicals) in waste activated sludge (WAS) would pose environmental risks for WAS …
Parachlorometaxylenol stress caused multidrug-type antibiotic resistance genes proliferation via simultaneously reshaping microbial community and interfering …
W Cao, W Du, S Fang, Q Wu, Z Wei, Z Xie, Y Su… - Environmental …, 2024 - Elsevier
Despite biological wastewater treatment processes (eg, sequencing batch reactors (SBR))
being able to reduce the dissemination of antibiotic resistance genes (ARGs), the variation …
being able to reduce the dissemination of antibiotic resistance genes (ARGs), the variation …
Network modeling-based identification of the switching targets between pyroptosis and secondary pyroptosis
The newly identified cell death type, pyroptosis plays crucial roles in various diseases. Most
recently, mounting evidence accumulates that pyroptotic signaling is highly correlated with …
recently, mounting evidence accumulates that pyroptotic signaling is highly correlated with …
A unified approach to dissecting biphasic responses in cell signaling
V Ramesh, J Krishnan - Elife, 2023 - elifesciences.org
Biphasic responses are encountered at all levels in biological systems. At the cellular level,
biphasic dose-responses are widely encountered in cell signaling and post-translational …
biphasic dose-responses are widely encountered in cell signaling and post-translational …
scGIR: deciphering cellular heterogeneity via gene ranking in single-cell weighted gene correlation networks
Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for investigating
cellular heterogeneity through high-throughput analysis of individual cells. Nevertheless …
cellular heterogeneity through high-throughput analysis of individual cells. Nevertheless …
The spring-like effect of microRNA-31 in balancing inflammatory and regenerative responses in colitis
Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders caused by the
disruption of immune tolerance to the gut microbiota. MicroRNA-31 (MIR31) has been …
disruption of immune tolerance to the gut microbiota. MicroRNA-31 (MIR31) has been …
[HTML][HTML] Incoherent feedforward loop dominates the robustness and tunability of necroptosis biphasic, emergent, and coexistent dynamics
Biphasic dynamics, the variable-dependent ability to enhance or restrain biological function,
is prevalent in natural systems. Accompanied by biphasic dynamics, necroptosis signaling …
is prevalent in natural systems. Accompanied by biphasic dynamics, necroptosis signaling …
Topological design principle for the robustness of necroptosis biphasic, emergent, and coexistent (BEC) dynamics
Biphasic dynamics, the variable-dependent ability to enhance or restrain biological function,
is prevalent in natural systems. Accompanied by biphasic dynamics, necroptosis signaling …
is prevalent in natural systems. Accompanied by biphasic dynamics, necroptosis signaling …