Stem cells demonstrate considerable promise for various preclinical and clinical
applications, including drug screening, disease treatments, and regenerative medicine …

Currently, the fabrication of a functional vascular network to maintain the viability of
engineered tissues is a major bottleneck in the way of developing a more advanced …

The natural healing process of bone is impaired in the presence of tumors, trauma, or
inflammation, necessitating external assistance for bone regeneration. The limitations of …

Background Cancer is a complex heterogeneous disease to which singular modes of
treatment mostly fail to produce a desired therapeutic efficacy. Targeting different cellular …

Currently, most in vitro engineered bone tissues do not contain viable blood vessel systems,
so the vascularization depends on post-implantation angiogenesis from the host, which is …

Despite the recent advances in reconstructive orthopedics; fracture union is a challenge to
bone regeneration. Concurrent angiogenesis is a complex process governed by events …

Inadequate vascularization is a significant barrier to clinical application of large-volume
tissue engineered grafts. In contrast to in vivo vascularization, in vitro prevascularization …

Longitudinal in vivo monitoring is essential for the design and evaluation of biomaterials. An
ideal method would provide three-dimensional quantitative information, high spatial …

In vitro prevascularization has the potential to address the challenge of maintaining cell
viability at the core of engineered constructs, such as bone substitutes, and to improve the …

Acquired cranial defects are a prevalent condition in neurosurgery and call for cranioplasty,
where the missing or defective cranium is replaced by an implant. Nevertheless, the …