Regulatory mechanism of M1/M2 macrophage polarization in the development of autoimmune diseases

Y Peng, M Zhou, H Yang, R Qu, Y Qiu… - Mediators of …, 2023 - Wiley Online Library
Macrophages are innate immune cells in the organism and can be found in almost tissues
and organs. They are highly plastic and heterogeneous cells and can participate in the …

Extracellular vesicles arising from apoptosis: Forms, functions, and applications

CD Gregory, MP Rimmer - The Journal of Pathology, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are lipid bilayer‐enclosed subcellular bodies produced by most,
if not all cells. Research over the last two decades has recognised the importance of EVs in …

Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis

N Yang, M Li, L Wu, Y Song, S Yu, Y Wan… - Journal of …, 2023 - Springer
Macrophage polarization determines the production of cytokines that fuel the initiation and
evolution of rheumatoid arthritis (RA). Thus, modulation of macrophage polarization might …

Messenger nanozyme for reprogramming the microenvironment of rheumatoid arthritis

M Jia, W Ren, Y Liu, C Wang, X Zheng… - … applied materials & …, 2022 - ACS Publications
Dysregulation of superoxide anion (O2–) and hydrogen peroxide (H2O2) metabolism in the
microenvironment of rheumatoid arthritis (RA) drives the feedback loops of TNF-α and IL-1β …

Advancements in extracellular vesicle targeted therapies for rheumatoid arthritis: insights into cellular origins, current perspectives, and emerging challenges

MT Jouybari, F Mojtahedi, M Babaahmadi… - Stem Cell Research & …, 2024 - Springer
Rheumatoid arthritis (RA) remains a challenging chronic autoimmune disorder
characterized by persistent joint inflammation and damage. While modern regenerative …

Immunomodulatory potential of mesenchymal stem cell-derived extracellular vesicles: Targeting immune cells

X Liu, Q Wei, L Lu, S Cui, K Ma, W Zhang, F Ma… - Frontiers in …, 2023 - frontiersin.org
Various intractable inflammatory diseases caused by disorders of immune systems have
pressed heavily on public health. Innate and adaptive immune cells as well as secreted …

Macrophage-hitchhiking interleukin-10 plasmid DNA delivery system modulates rheumatoid arthritis microenvironment via the re-polarization of macrophages

X Zhang, Y Liu, W Liu, L Chen, M Jin, Z Gao, W Huang - Nano Today, 2024 - Elsevier
Rheumatoid arthritis (RA) is a common chronic inflammatory disease and the current
treatments for RA are unsatisfactory due to the buffer barrier from the RA microenvironment …

Inflammation specific environment activated methotrexate-loaded nanomedicine to treat rheumatoid arthritis by immune environment reconstruction

J Tian, T Chen, B Huang, Y Liu, C Wang, Z Cui, H Xu… - Acta Biomaterialia, 2023 - Elsevier
Rheumatoid arthritis (RA), as an autoimmune inflammatory disease, is featured by
enhanced vascular permeability, irreversible cartilage destroys and bone erosion. Although …

[HTML][HTML] Global scientific trends update on macrophage polarization in rheumatoid arthritis: A bibliometric and visualized analysis from 2000 to 2022

J Yuan, T Feng, Y Guo, K Luo, Q Wu, S Yu, H Zhou - Heliyon, 2023 - cell.com
The goal of this work was to use bibliometric analysis to help guide future research on
macrophage polarization in RA. We looked for studies on macrophage polarization in RA …

Roles of extracellular vesicles on macrophages in inflammatory bone diseases

Y Lin, Z Wang, S Liu, J Liu, Z Zhang, Y Ouyang… - Molecular and Cellular …, 2024 - Springer
Inflammatory bone disease is a general term for a series of diseases caused by chronic
inflammation, which leads to the destruction of bone homeostasis, that is, the osteolytic …