Abstract E1, an ATP-dependent DNA helicase, is the only enzyme encoded by
papillomaviruses (PVs). It is essential for replication and amplification of the viral episome in …

Replication of the two template strands at eukaryotic cell DNA replication forks is a highly
coordinated process that ensures accurate and efficient genome duplication. Biochemical …

Productive infection by human papillomaviruses (HPV) is dependent upon the differentiation
of the host cell. Following entry into basal epithelial cells, HPV genomes are established as …

The eukaryotic replisome is a crucial determinant of genome stability, but its structure is still
poorly understood. We found previously that many regulatory proteins assemble around the …

Viruses employ a variety of strategies to usurp and control cellular activities through the
orchestrated recruitment of macromolecules to specific cytoplasmic or nuclear …

Synthesis of all genomic DNA involves the highly coordinated action of multiple
polypeptides. These proteins assemble two new DNA chains at a remarkable pace …

The study of human papillomavirus type 16 (HPV-16) replication has been impaired
because of the lack of a cell culture system that stably maintains viral replication. Recently …

An important reason for preferring mammalian cells for heterologous gene expression is
their ability to make authentic proteins containing post‐translational modifications similar to …

The E1 proteins are the essential origin recognition proteins for papillomavirus (PV)
replication. E1 proteins bind to specific DNA elements in the viral origin of replication and …

The human papillomavirus (HPV) E1 and E2 proteins bind cooperatively to the viral origin of
replication (ori), forming an E1-E2-ori complex that is essential for initiation of DNA …