CCR6-CCL20 axis as a therapeutic target for autoimmune diseases
Chemokine receptor CCR6 is expressed on various cells such as B cells, immature dendritic
cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only …
cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only …
Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease
Immune cell trafficking is a critical element of the intestinal immune response, both in
homeostasis and in pathological conditions associated with inflammatory bowel disease …
homeostasis and in pathological conditions associated with inflammatory bowel disease …
Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome
C Kong, X Yan, Y Liu, L Huang, Y Zhu, J He… - Signal transduction and …, 2021 - nature.com
Accumulating evidence suggests that ketogenic diets (KDs) mediate the rise of circulating
ketone bodies and exert a potential anti-inflammatory effect; however, the consequences of …
ketone bodies and exert a potential anti-inflammatory effect; however, the consequences of …
[HTML][HTML] Biological drug and drug delivery-mediated immunotherapy
The initiation and development of major inflammatory diseases, ie, cancer, vascular
inflammation, and some autoimmune diseases are closely linked to the immune system …
inflammation, and some autoimmune diseases are closely linked to the immune system …
Human intestinal macrophages are involved in the pathology of both ulcerative colitis and Crohn disease
S Dharmasiri, EM Garrido-Martin… - Inflammatory bowel …, 2021 - academic.oup.com
Background Intestinal macrophages are key immune cells in the maintenance of intestinal
immune homeostasis and have a role in the pathogenesis of inflammatory bowel disease …
immune homeostasis and have a role in the pathogenesis of inflammatory bowel disease …
Cross-talk between the gut microbiota and monocyte-like macrophages mediates an inflammatory response to promote colitis-associated tumourigenesis
Y Yang, L Li, C Xu, Y Wang, Z Wang, M Chen, Z Jiang… - Gut, 2021 - gut.bmj.com
Objective Macrophages are among the most abundant cells in the colon tumour
microenvironment, and there is a close relationship among monocytes, macrophages and …
microenvironment, and there is a close relationship among monocytes, macrophages and …
Clinical significance of chemokine receptor antagonists
M Miao, E De Clercq, G Li - Expert Opinion on Drug Metabolism & …, 2020 - Taylor & Francis
Introduction: Chemokine receptors are important therapeutic targets for the treatment of
many human diseases. This study will provide an overview of approved chemokine receptor …
many human diseases. This study will provide an overview of approved chemokine receptor …
Development of antifibrotic therapy for stricturing Crohn's disease: lessons from randomized trials in other fibrotic diseases
Intestinal fibrosis is considered an inevitable complication of Crohn's disease (CD) that
results in symptoms of obstruction and stricture formation. Endoscopic or surgical treatment …
results in symptoms of obstruction and stricture formation. Endoscopic or surgical treatment …
Rhein regulates redox‐mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage‐activated crosstalk
Background and Purpose Macrophage infiltration and activation is a critical step during
acute colitis. Redox‐mediated activation of NLRP3 inflammasomes in macrophages plays a …
acute colitis. Redox‐mediated activation of NLRP3 inflammasomes in macrophages plays a …
A specific calprotectin neo-epitope [CPa9-HNE] in serum from inflammatory bowel disease patients is associated with neutrophil activity and endoscopic severity
JH Mortensen, D Sinkeviciute… - Journal of Crohn's …, 2022 - academic.oup.com
Abstract Background and Aims Endoscopy and the use of faecal calprotectin [faecal CP] are
among the least-favoured methods for assessing disease activity by inflammatory bowel …
among the least-favoured methods for assessing disease activity by inflammatory bowel …