The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

Background The inability to have children affects 10% to 15% of couples worldwide. A male
factor is estimated to account for up to half of the infertility cases with between 25% to 87% of …

Vitamin D deficiency is common and there exists a huge gap between recommended dietary
vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is …

In the last decade, vitamin D has emerged as a pleiotropic molecule with a multitude of
autocrine, paracrine and endocrine functions, mediated by classical genomic as well as non …

STUDY QUESTION Is adherence to the Mediterranean diet (MedDiet) associated with better
semen quality in men of subfertile couples attempting fertility? SUMMARY ANSWER Greater …

Context Results of animal models and cross-sectional cohort studies have suggested a
beneficial role for vitamin D in male reproduction. Objective Determine the effect of vitamin D …

Although the kidney was initially thought to be the sole organ responsible for the production
of 1, 25 (OH) 2 D via the enzyme CYP27b1, it is now appreciated that the expression of …

STUDY QUESTION Are low vitamin D levels linked with semen quality and sex steroids in
infertile men? SUMMARY ANSWER Infertile men with vitamin D deficiency had lower sperm …

Background Physical activity (PA) and sedentary behavior have inconsistent effects on
fertility. High body mass index is associated with infertility but to our knowledge, very few …