In this study, we designed, synthesized, and evaluated a series of carbamate derivatives of
N-salicyloyl tryptamine as multifunctional therapeutic agents for the treatment of Alzheimer's …

Alzheimer's disease (AD) is a progressive neurological illness that is distinguished clinically
by cognitive and memory decline and adversely affects the people of old age. The …

Butyrylcholinesterase (BChE), also known as pseudocholinesterase and serum
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …

A series of novel quinoline-O-carbamate derivatives was rationally designed for treating
Alzheimer's disease (AD) by multi-target-directed ligands (MTDLs) strategy. The target …

In this study, two series of compounds were designed and synthesized, bearing thiourea
and benzamide derivatives at position 2 of 4-subtituted-2-aminothiazole, respectively. Then …

An atom economic β-C (sp 3)− H chlorination of amide derivatives has been developed. This
mild protocol employs CuCl 2 instead of palladium catalysts with atom-economic HCl as …

Despite the great effort that has gone into developing new molecules as multitarget
compounds to treat Alzheimer's disease (AD), none of these have been approved to treat …

A novel series of carbamate-based N-substituted tryptamine derivatives were designed and
synthesized based on functional group combination strategy, and possessed both …

Two novel series of tryptanthrin (TRYP) derivatives were designed and synthesized as
multifunctional agents for the treatment of Alzheimer's disease (AD). Inhibition assay against …

A series of 19 novel α-aminophosphonate-tetrahydroisoquinoline hybrids were synthesized
through a cross dehydrogenative coupling reaction between N-aryl-tetrahydroisoquinolines …