The selective insertion of oxygen into non-activated organic molecules has to date been
considered of utmost importance to synthesize existing and next generation industrial …

In 2004, the fungal heme-thiolate enzyme subfamily of unspecific peroxygenases (UPOs)
was first described in the basidiomycete Agrocybe aegerita. As UPOs naturally catalyze a …

Enzymatic hydroxylation of activated and nonactivated sp3-carbons attracts keen interest
from the chemistry community as it is one of the most challenging tasks in organic synthesis …

Abstract Changes in cytosolic calcium (Ca2+) concentration are among the earliest
reactions to a multitude of stress cues. While a plethora of Ca2+-permeable channels may …

Unspecific peroxygenases (UPOs) perform oxyfunctionalizations for a wide range of
substrates utilizing H2O2 without the need for further reductive equivalents or electron …

Fungal unspecific peroxygenases (UPOs) represent an enzyme class catalysing versatile
oxyfunctionalisation reactions on a broad substrate scope. They are occurring as secreted …

Fungal unspecific peroxygenases (UPOs) have gained substantial attention for their
versatile oxyfunctionalization chemistry paired with impressive catalytic capabilities. A major …

High-throughput experimentation (HTE) is a well-established technique used in the
pharmaceutical industry to accelerate compound synthesis and route optimization through …

Unspecific peroxygenases (UPOs) enable oxyfunctionalizations of a broad substrate range
with unparalleled activities. Tailoring these enzymes for chemo-and regioselective …

C− H oxyfunctionalisation remains a distinct challenge for synthetic organic chemists.
Oxygenases and peroxygenases (grouped here as “oxygenating biocatalysts”) catalyse the …