Regulation of intestinal homeostasis and immunity with probiotic lactobacilli

P van Baarlen, JM Wells, M Kleerebezem - Trends in immunology, 2013 - cell.com
The gut microbiota provide important stimuli to the human innate and adaptive immune
system and co-mediate metabolic and immune homeostasis. Probiotic bacteria can be …

The intestinal microbiota in inflammatory bowel disease

C Becker, MF Neurath, S Wirtz - ILAR journal, 2015 - academic.oup.com
The intestinal microbiota has important metabolic and host-protective functions. Conversely
to these beneficial functions, the intestinal microbiota is thought to play a central role in the …

[HTML][HTML] Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells

AM Ehrlich, AR Pacheco, BM Henrick, D Taft, G Xu… - BMC microbiology, 2020 - Springer
Background Bifidobacterium longum subsp. infantis (B. infantis) is a commensal bacterium
that colonizes the gastrointestinal tract of breast-fed infants. B. infantis can efficiently utilize …

[HTML][HTML] Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants

ZT Lewis, SM Totten, JT Smilowitz, M Popovic, E Parker… - Microbiome, 2015 - Springer
Background Individuals with inactive alleles of the fucosyltransferase 2 gene (FUT2; termed
the 'secretor'gene) are common in many populations. Some members of the genus …

[HTML][HTML] Growth and morbidity of Gambian infants are influenced by maternal milk oligosaccharides and infant gut microbiota

JCC Davis, ZT Lewis, S Krishnan, RM Bernstein… - Scientific reports, 2017 - nature.com
Human milk oligosaccharides (HMOs) play an important role in the health of an infant as
substrate for beneficial gut bacteria. Little is known about the effects of HMO composition …

[HTML][HTML] Probiotic engineering: towards development of robust probiotic strains with enhanced functional properties and for targeted control of enteric pathogens

MG Mathipa, MS Thantsha - Gut pathogens, 2017 - Springer
There is a growing concern about the increase in human morbidity and mortality caused by
foodborne pathogens. Antibiotics were and still are used as the first line of defense against …

Bifidobacteria isolated from infants and cultured on human milk oligosaccharides affect intestinal epithelial function

M Chichlowski, G De Lartigue, JB German… - Journal of pediatric …, 2012 - journals.lww.com
Objectives: Human milk oligosaccharides (HMOs) are the third most abundant component of
breast milk. Our laboratory has previously revealed gene clusters specifically linked to HMO …

The mechanism of action of probiotics

M Boirivant, W Strober - Current opinion in gastroenterology, 2007 - journals.lww.com
This review of probiotics and inflammatory bowel disease marshals support for the concept
that administration of probiotics ameliorates inflammation by exerting positive effects on the …

Mechanisms of probiotic action: implications for therapeutic applications in inflammatory bowel diseases

C Vanderpool, F Yan, BD Polk - Inflammatory bowel diseases, 2008 - academic.oup.com
Probiotics are defined as nonpathogenic living microorganisms, including some commensal
bacterial flora, which have beneficial effects on host health and disease prevention and/or …

Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response

HK Kwon, GC Kim, Y Kim, W Hwang, A Jash… - Clinical …, 2013 - Elsevier
The immunomodulatory effect of probiotics has been shown mainly in gastro-intestinal
immune disorders and little information is available on the inflammation of central nervous …