Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …

Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

Tumor-derived exosomes are emerging mediators of tumorigenesis and tissue-specific
metastasis. Proteomic profiling has identified Annexin II as one of the most highly expressed …

The general progression of cancer drug development involves in vitro testing followed by
safety and efficacy evaluation in clinical trials. Due to the expense of bringing candidate …

Tumors can undergo long periods of dormancy, with cancer cells entering a largely
quiescent, nonproliferative state before reactivation and outgrowth. To understand the role of …

The dynamic epigenetic landscape directs gene expression patterns that dictate cellular
form and function, and drive the assembly of cells into tissues. The high degree of plasticity …

The pre-metastatic niche—the accumulation of aberrant immune cells and extracellular-
matrix proteins in target organs—primes the initially healthy organ microenvironment and …

The metabolite acetyl-coenzyme A (acetyl-CoA) is the required acetyl donor for lysine
acetylation and thereby links metabolism, signaling, and epigenetics. Nutrient availability …

Cancer is one of the leading causes of death globally according to the World Health
Organization. Although improved treatments and early diagnoses have reduced cancer …

Cancer cells have the ability to migrate from the primary (original) site to other places in the
body. The extracellular matrix affects cancer cell migratory capacity and has been correlated …