X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …

Regulatory landscapes drive complex developmental gene expression, but it remains
unclear how their integrity is maintained when incorporating novel genes and functions …

X-chromosome inactivation (XCI) balances gene expression between the sexes in female
mammals. Shortly after fertilization, upregulation of Xist RNA from one X chromosome …

XX female and XY male therian mammals equalize X-linked gene expression through the
mitotically-stable transcriptional inactivation of one of the two X chromosomes in female …

In female eutherian mammals, dosage compensation of X-linked gene expression is
achieved during development through transcriptional silencing of one of the two X …

X chromosome inactivation (XCI) serves as a paradigm for RNA-mediated regulation of
gene expression, wherein the long non-coding RNA XIST spreads across the X …

Early in development, placental and marsupial mammals harbouring at least two X
chromosomes per nucleus are faced with a choice that affects the rest of their lives: which of …

It is apparent that various functional units within the cellular machinery are derived from
RNAs. The evolution of sequencing techniques has resulted in significant insights into …

Highlights•Complex regulatory interactions ensure female-specific monoallelic Xist
expression.•Stochastic upregulation combined with a negative feedback can explain the Xist …