During the past two decades the first sequencing of the human genome was performed
showing its high degree of inter-individual differentiation, as a result of large international …

BACKGROUND: Over the past decades, significant progress has been achieved in the
cytotoxic treatment of colorectal cancer (CRC) by the use of fluoropyrimidines, irinotecan …

Purpose: The natural history and prognosis of appendiceal adenocarcinomas differ from
those of adenocarcinomas arising in other large bowel sites. We aimed to compare the …

Colorectal cancer (CRC) is the second most common cause of death worldwide, affecting
approximately 1.9 million individuals in 2020. Therapeutics of the disease are not yet …

Ezrin is a membrane-cytoskeleton anchor, which, in experimental models, regulates tumor
cell invasion and metastatic ability. We carried out immunohistochemical analysis of ezrin in …

Purpose To evaluate the clinical activity and toxicity of capecitabine plus irinotecan as first-
line therapy for patients with metastatic colorectal cancer (mCRC), and to describe the …

The published data about thymidylate synthase (TS) expression and its predictive value in
advanced colorectal cancer (CRC) patients receiving fluoropyrimidine‐based chemotherapy …

The monoclonal antibody cetuximab directed against the epidermal growth factor receptor
(EGFR) is an attractive agent for targeted therapy in advanced colorectal cancer (CRC) …

Background. Colorectal cancer (CRC) cell lines displaying microsatellite instability (MSI) are
resistant to 5-fluorouracil (5-FU) in vitro, which can be overcome by restoring DNA mismatch …

AIM: To examine the expression of thymidylate synthase (TS) and oncoprotein Bcl-2 in
advanced colorectal cancer (CRC) patients, and to determine their mutual relationship …