[HTML][HTML] The biological function of the prion protein: a cell surface scaffold of signaling modules
R Linden - Frontiers in molecular neuroscience, 2017 - frontiersin.org
The prion glycoprotein (PrPC) is mostly located at the cell surface, tethered to the plasma
membrane through a glycosyl-phosphatydil inositol (GPI) anchor. Misfolding of PrPC is …
membrane through a glycosyl-phosphatydil inositol (GPI) anchor. Misfolding of PrPC is …
Prion protein misfolding
L Kupfer, W Hinrichs… - Current molecular …, 2009 - ingentaconnect.com
The crucial event in the development of transmissible spongiform encephalopathies (TSEs)
is the conformational change of a host-encoded membrane protein-the cellular PrPC-into a …
is the conformational change of a host-encoded membrane protein-the cellular PrPC-into a …
Clade‐specific differences in neurotoxicity of human immunodeficiency virus‐1 B and C Tat of human neurons: significance of dicysteine C30C31 motif
M Mishra, S Vetrivel, NB Siddappa… - Annals of …, 2008 - Wiley Online Library
Objective Human immunodeficiency virus‐1 (HIV‐1) causes mild to severe cognitive
impairment and dementia. The transactivator viral protein, Tat, is implicated in neuronal …
impairment and dementia. The transactivator viral protein, Tat, is implicated in neuronal …
[HTML][HTML] Selective processing and metabolism of disease-causing mutant prion proteins
A Ashok, RS Hegde - PLoS pathogens, 2009 - journals.plos.org
Prion diseases are fatal neurodegenerative disorders caused by aberrant metabolism of the
cellular prion protein (PrPC). In genetic forms of these diseases, mutations in the globular C …
cellular prion protein (PrPC). In genetic forms of these diseases, mutations in the globular C …
Optimizing cathode materials for intermediate-temperature solid oxide fuel cells (SOFCs): Oxygen reduction on nanostructured lanthanum nickelate oxides
JSA Carneiro, RA Brocca, MLRS Lucena… - Applied Catalysis B …, 2017 - Elsevier
Kinetics of high temperature oxygen reduction reaction (ORR) on La 2 NiO 4+ δ (LNO)
nanostructures are investigated by means of electrochemical impedance spectroscopy, with …
nanostructures are investigated by means of electrochemical impedance spectroscopy, with …
[HTML][HTML] Regional variability and genotypic and pharmacodynamic effects on PrP concentration in the CNS
MA Mortberg, HT Zhao, AG Reidenbach, JE Gentile… - JCI insight, 2022 - ncbi.nlm.nih.gov
Prion protein (PrP) concentration controls the kinetics of prion replication and is a genetically
and pharmacologically validated therapeutic target for prion disease. In order to evaluate …
and pharmacologically validated therapeutic target for prion disease. In order to evaluate …
[HTML][HTML] De novo generation of infectious prions with bacterially expressed recombinant prion protein
Z Zhang, Y Zhang, F Wang, X Wang, Y Xu… - The FASEB …, 2013 - ncbi.nlm.nih.gov
The prion hypothesis is strongly supported by the fact that prion infectivity and the
pathogenic conformer of prion protein (PrP) are simultaneously propagated in vitro by the …
pathogenic conformer of prion protein (PrP) are simultaneously propagated in vitro by the …
Prion protein biosynthesis and its emerging role in neurodegeneration
O Chakrabarti, A Ashok, RS Hegde - Trends in biochemical sciences, 2009 - cell.com
Various fatal neurodegenerative disorders are caused by altered metabolism of the prion
protein (PrP). These diseases are typically transmissible by an unusual 'protein …
protein (PrP). These diseases are typically transmissible by an unusual 'protein …
The prion protein unstructured N‐terminal region is a broad‐spectrum molecular sensor with diverse and contrasting potential functions
M Béland, X Roucou - Journal of neurochemistry, 2012 - Wiley Online Library
J. Neurochem.(2012) 120, 853–868. Abstract The physiological function of the prion protein
(PrPC) and its conversion into its infectious form (PrPSc) are central issues to understanding …
(PrPC) and its conversion into its infectious form (PrPSc) are central issues to understanding …
Role of the highly conserved middle region of prion protein (PrP) in PrP− lipid interaction
F Wang, S Yin, X Wang, L Zha, MS Sy, J Ma - Biochemistry, 2010 - ACS Publications
Converting normal prion protein (PrPC) to the pathogenic PrPSc isoform is central to prion
disease. We previously showed that, in the presence of lipids, recombinant mouse PrP …
disease. We previously showed that, in the presence of lipids, recombinant mouse PrP …