Noncovalent, extrinsic fluorescent dyes are applied in various fields of protein analysis, eg to
characterize folding intermediates, measure surface hydrophobicity, and detect aggregation …

Large‐scale characterization of post‐translational modifications (PTM s), such as
phosphorylation, acetylation and ubiquitination, has highlighted their importance in the …

Chemical modification and immobilization of enzymes have been usually considered
unrelated tools to improve biocatalyst features. However, there are many examples where a …

One of the first hurdles to be negotiated in the postgenomic era involves the description of
the entire protein content of the cell, the proteome. Such efforts are presently complicated by …

Thermophilic proteins show substantially higher intrinsic thermal stability than their
mesophilic counterparts. Amino acid composition is believed to alter the intrinsic stability of …

The dynamic modification of histone proteins by lysine methylation has emerged over the
last decade as a key regulator of chromatin functions. In contrast, our understanding of the …

In order to survive at high temperatures, thermophilic prokaryotes (Archaea and Eubacteria)
adopt different strategies. Among several important contributing factors for stability of …

Integrin signaling may modulate several different functions involved in cell migration,
invasion, proliferation and motility, and is a potential candidate biomarker for oral cancer. In …

Protein post-translational methylation has been reported to occur in archaea, including
members of the genus Sulfolobus, but has never been characterized on a proteome-wide …

The deposition of insoluble protein aggregates in the brain is a hallmark of many
neurodegenerative diseases. While their exact role in neurodegeneration remains unclear …