Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

Neurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …

The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end
of the century to identify the components of pathological hallmarks and genetic subtypes and …

Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD),
the neurofibrillary tangles, and is therefore of major interest as an indicator of disease …

Amyloid-β (Aβ) and tau proteins currently represent the two most promising targets to treat
Alzheimer's disease. The most extensively developed method to treat the pathologic forms of …

Abnormal deposition of misprocessed and aggregated proteins is a common final pathway
of most neurodegenerative diseases, including Alzheimer's disease (AD). AD is …

Perhaps no disorder of the human brain has aroused more interest among neuroscientists in
recent years than Alzheimer's disease (AD). This common and devastating cerebral …

Alzheimer's disease begins about two decades before the onset of symptoms or neuron
death, and is believed to be caused by pathogenic amyloid-β aggregates that initiate a …

Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer
disease (AD) by affecting the formation of the amyloid β (Aβ) peptide, the major constituent …

The major protein subunit of the paired helical filaments (PHF) of Alzheimer disease (AD) is
the microtubule-associated protein tau. Tau is a family of phosphopolypeptides that are …