Thermoresponsive polymers and their biomedical application in tissue engineering–a review

F Doberenz, K Zeng, C Willems, K Zhang… - Journal of Materials …, 2020 - pubs.rsc.org
Thermoresponsive polymers hold great potential in the biomedical field, since they enable
the fabrication of cell sheets, in situ drug delivery and 3D-printing under physiological …

Poly (N-isopropylacrylamide)-based thermoresponsive surfaces provide new types of biomedical applications

K Nagase, M Yamato, H Kanazawa, T Okano - Biomaterials, 2018 - Elsevier
Thermoresponsive surfaces, prepared by grafting of poly (N-isopropylacrylamide)(PIPAAm)
or its copolymers, have been investigated for biomedical applications. Thermoresponsive …

Thermoresponsive interfaces obtained using poly (N-isopropylacrylamide)-based copolymer for bioseparation and tissue engineering applications

K Nagase - Advances in Colloid and Interface Science, 2021 - Elsevier
Abstract Poly (N-isopropylacrylamide)(PNIPAAm) is the most well-known and widely used
stimuli-responsive polymer in the biomedical field owing to its ability to undergo temperature …

Cell sheet approach for tissue engineering and regenerative medicine

K Matsuura, R Utoh, K Nagase, T Okano - Journal of Controlled Release, 2014 - Elsevier
After the biotech medicine era, regenerative medicine is expected to be an advanced
medicine that is capable of curing patients with difficult-to-treat diseases and physically …

Cell sheet technology: a promising strategy in regenerative medicine

M Li, JUN Ma, Y Gao, LEI Yang - Cytotherapy, 2019 - Elsevier
Regenerative medicine is a burgeoning field that is important to combat challenging
diseases and functional impairments. Compared with traditional cell therapies with evident …

Scaffold‐free bio‐3D printing using spheroids as “Bio‐Inks” for tissue (Re‐) construction and drug response tests

D Murata, K Arai, K Nakayama - Advanced Healthcare …, 2020 - Wiley Online Library
In recent years, scaffold‐free bio‐3D printing using cell aggregates (spheroids) as “bio‐inks”
has attracted increasing attention as a method for 3D cell construction. Bio‐3D printing uses …

Cell sheet engineering and its application for periodontal regeneration

T Iwata, K Washio, T Yoshida, I Ishikawa… - Journal of tissue …, 2015 - Wiley Online Library
Periodontitis is a inflammation induced by a bacterial infection that causes the destruction of
the attachment apparatus of dental roots. Several materials, such as bone graft materials …

Controlled chain length and graft density of thermoresponsive polymer brushes for optimizing cell sheet harvest

H Takahashi, M Nakayama, M Yamato… - …, 2010 - ACS Publications
Novel thermoresponsive polymer brush surfaces for harvesting cell sheet were fabricated by
the surface-initiated RAFT polymerization of N-isopropylacrylamide (IPAAm) on azoinitiator …

Micropatterned thermoresponsive polymer brush surfaces for fabricating cell sheets with well-controlled orientational structures

H Takahashi, M Nakayama, K Itoga, M Yamato… - …, 2011 - ACS Publications
Newly developed fabrication technique of thermoresponsive surface using RAFT-mediated
block copolymerization and photolithography achieved stripe-like micropatterning of poly (N …

Application of the cell sheet technique in tissue engineering

G Chen, Y Qi, L Niu, T Di, J Zhong… - Biomedical …, 2015 - spandidos-publications.com
The development and application of the tissue engineering technique has shown a
significant potential in regenerative medicine. However, the limitations of conventional tissue …