Macrophage activities in myocardial infarction and heart failure
SE Duncan, S Gao, M Sarhene… - Cardiology …, 2020 - Wiley Online Library
Heart diseases remain the major cause of death worldwide. Advances in pharmacological
and biomedical management have resulted in an increasing proportion of patients surviving …
and biomedical management have resulted in an increasing proportion of patients surviving …
Macrophage mediators and mechanisms in cardiovascular disease
P Schelemei, E Wagner, FSR Picard… - The FASEB …, 2024 - Wiley Online Library
Macrophages are major players in myocardial infarction (MI) and atherosclerosis, two major
cardiovascular diseases (CVD). Atherosclerosis is caused by the buildup of cholesterol‐rich …
cardiovascular diseases (CVD). Atherosclerosis is caused by the buildup of cholesterol‐rich …
Targeting 5-HT2B Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling After Myocardial Infarction
Background: Myocardial infarction (MI) induces an intense injury response that ultimately
generates a collagen-dominated scar. Although required to prevent ventricular rupture, the …
generates a collagen-dominated scar. Although required to prevent ventricular rupture, the …
Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration
KH Wei, IT Lin, K Chowdhury, KL Lim, KT Liu, TM Ko… - Elife, 2023 - elifesciences.org
Zebrafish exhibit a robust ability to regenerate their hearts following injury, and the immune
system plays a key role in this process. We previously showed that delaying macrophage …
system plays a key role in this process. We previously showed that delaying macrophage …
Placental inflammation leads to abnormal embryonic heart development
EJ Ward, S Bert, S Fanti, KM Malone, RT Maughan… - Circulation, 2023 - Am Heart Assoc
Background: Placental heart development and embryonic heart development occur in
parallel, and these organs have been proposed to exert reciprocal regulation during …
parallel, and these organs have been proposed to exert reciprocal regulation during …
[HTML][HTML] Lactoferrin attenuates cardiac fibrosis and cardiac remodeling after myocardial infarction via inhibiting mTORC1/S6K signaling pathway
T Ye, Z Yan, C Chen, D Wang, A Wang, T Li, B Yang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: Myocardial infarction (MI) causes a severe injury response that eventually leads
to adverse cardiac remodeling and heart failure. Lactoferrin (Ltf), as a secreted protein …
to adverse cardiac remodeling and heart failure. Lactoferrin (Ltf), as a secreted protein …
Apoptosis recognition receptors regulate skin tissue repair in mice
Apoptosis and clearance of apoptotic cells via efferocytosis are evolutionarily conserved
processes that drive tissue repair. However, the mechanisms by which recognition and …
processes that drive tissue repair. However, the mechanisms by which recognition and …
Multiomics uncover the proinflammatory role of Trpm4 deletion after myocardial infarction in mice
M Boukenna, JS Rougier… - American Journal …, 2023 - journals.physiology.org
Upon myocardial infarction (MI), ischemia-induced cell death triggers an inflammatory
response responsible for removing necrotic material and inducing tissue repair. TRPM4 is a …
response responsible for removing necrotic material and inducing tissue repair. TRPM4 is a …
Apoptosis recognition receptors regulate skin tissue repair in mice
Apoptosis and clearance of apoptotic cells via efferocytosis are evolutionarily conserved
processes that drive tissue repair. However, the mechanisms by which recognition and …
processes that drive tissue repair. However, the mechanisms by which recognition and …