Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
Integrative hedonic and homeostatic food intake regulation by the central nervous system: insights from neuroimaging
Food intake regulation in humans is a complex process controlled by the dynamic
interaction of homeostatic and hedonic systems. Homeostatic regulation is controlled by …
interaction of homeostatic and hedonic systems. Homeostatic regulation is controlled by …
Palmitoylethanolamide in the treatment of chronic pain: a systematic review and meta-analysis of double-blind randomized controlled trials
K Lang-Illievich, C Klivinyi, C Lasser, CTA Brenna… - Nutrients, 2023 - mdpi.com
Chronic pain is a major source of morbidity for which there are limited effective treatments.
Palmitoylethanolamide (PEA), a naturally occurring fatty acid amide, has demonstrated utility …
Palmitoylethanolamide (PEA), a naturally occurring fatty acid amide, has demonstrated utility …
Inhibiting degradation of 2-arachidonoylglycerol as a therapeutic strategy for neurodegenerative diseases
C Chen - Pharmacology & therapeutics, 2023 - Elsevier
Endocannabinoids are endogenous lipid signaling mediators that participate in a variety of
physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most …
physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most …
[HTML][HTML] Frequent low-impact exposure to THC during adolescence causes persistent sexually dimorphic alterations in the response to viral infection in mice
Adolescent exposure to Δ 9-tetrahydrocannabinol (THC) has enduring effects on energy
metabolism and immune function. Prior work showed that daily administration of a low …
metabolism and immune function. Prior work showed that daily administration of a low …
[HTML][HTML] Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling
G protein-coupled receptors (GPCRs) exist within a landscape of interconvertible
conformational states and in dynamic equilibrium between monomers and higher-order …
conformational states and in dynamic equilibrium between monomers and higher-order …
Fatty acid amide hydrolase inhibition alleviates anxiety-like symptoms in a rat model used to study post-traumatic stress disorder
Background and aim Post-traumatic stress disorder (PTSD), a chronic debilitating condition
that affects nearly 5–10% of American adults, is treated with a handful of FDA-approved …
that affects nearly 5–10% of American adults, is treated with a handful of FDA-approved …
Combined targeting of fatty acid amide hydrolase and melatonin receptors promotes neuroprotection and stimulates inflammation resolution in rats
M Cammarota, F Ferlenghi, F Vacondio… - British Journal of …, 2023 - Wiley Online Library
Background and Purpose Devising novel strategies to therapeutically favour inflammation
resolution and provide neuroprotection is an unmet clinical need. Enhancing …
resolution and provide neuroprotection is an unmet clinical need. Enhancing …
[HTML][HTML] Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain
S Nobili, L Micheli, E Lucarini, A Toti… - Pharmacology & …, 2024 - Elsevier
Current epidemiological data estimate that one in five people suffers from chronic pain with
considerable impairment of health-related quality of life. The pharmacological treatment is …
considerable impairment of health-related quality of life. The pharmacological treatment is …